Version 5.4
Homo sapiens Gene: TRPC3
Summary
InnateDB Gene IDBG-36538.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRPC3
Gene Name transient receptor potential cation channel, subfamily C, member 3
Synonyms TRP3
Species Homo sapiens
Ensembl Gene ENSG00000138741
Encoded Proteins
IDBP-36540
transient receptor potential cation channel, subfamily C, member 3
IDBP-36542
transient receptor potential cation channel, subfamily C, member 3
IDBP-476653
transient receptor potential cation channel, subfamily C, member 3
IDBP-474007
transient receptor potential cation channel, subfamily C, member 3
IDBP-476553
transient receptor potential cation channel, subfamily C, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:121879027-121951754
Strand Reverse strand
Band q27
Transcripts
ENST00000379645 ENSP00000368966
ENST00000264811 ENSP00000264811
ENST00000506449 ENSP00000423866
ENST00000513531 ENSP00000426899
ENST00000502968 ENSP00000422214
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005262 calcium channel activity
GO:0005488 binding
GO:0005515 protein binding
GO:0015279 store-operated calcium channel activity
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0007602 phototransduction
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0030168 platelet activation
GO:0033198 response to ATP
GO:0034220 ion transmembrane transport
GO:0051592 response to calcium ion
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027716
View Gene Order
ENSBTAG00000019021
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_162
Elevation of cytosolic Ca2+ levels pathway
REACT_23876
Platelet homeostasis pathway
REACT_2202
Effects of PIP2 hydrolysis pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_22228
Role of second messengers in netrin-1 signaling pathway
REACT_22237
Netrin-1 signaling pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_111045
Developmental Biology pathway
REACT_23905
Platelet calcium homeostasis pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_25300
Ion channel transport pathway
REACT_169333
TRP channels pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
pi3kplctrkpathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Cross-References
SwissProt
TrEMBL D6R902 J3QTB0 Q4W5P7
UniProt Splice Variant
Entrez Gene 7222
UniGene Hs.150981 Hs.629907
RefSeq NM_001130698 NM_003305 XM_006714296
HUGO HGNC:12335
OMIM 602345
CCDS CCDS3725 CCDS47130
HPRD 15999
IMGT
EMBL AC079341 AC108930
GenPept AAY40971
RNA Seq Atlas 7222

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca