InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HYAL2

Summary

InnateDB Gene

IDBG-36557.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HYAL2

Gene Name

hyaluronoglucosaminidase 2

Synonyms

LUCA2

Species

Homo sapiens

Ensembl Gene

ENSG00000068001

Encoded Proteins

IDBP-36559

hyaluronoglucosaminidase 2

IDBP-240167

hyaluronoglucosaminidase 2

IDBP-378225

hyaluronoglucosaminidase 2

IDBP-378226

hyaluronoglucosaminidase 2

IDBP-378229

hyaluronoglucosaminidase 2

IDBP-378231

hyaluronoglucosaminidase 2

IDBP-378236

hyaluronoglucosaminidase 2

IDBP-378238

hyaluronoglucosaminidase 2

IDBP-378240

hyaluronoglucosaminidase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010]
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5\' UTR.[provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:50317790-50322906

Strand

Reverse strand

Band

p21.31

Transcripts

ENST00000357750	ENSP00000350387
ENST00000395139	ENSP00000378571
ENST00000447092	ENSP00000401853
ENST00000442581	ENSP00000406657
ENST00000458018	ENSP00000399677
ENST00000424190	ENSP00000398714
ENST00000426286	ENSP00000409642
ENST00000428028	ENSP00000414656
ENST00000415028	ENSP00000405855
ENST00000481597

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0004415	hyalurononglucosaminidase activity
GO:0005515	protein binding
GO:0005540	hyaluronic acid binding
GO:0019899	enzyme binding
GO:0030294	receptor signaling protein tyrosine kinase inhibitor activity
GO:0030971	receptor tyrosine kinase binding
GO:0033906	hyaluronoglucuronidase activity
GO:0050431	transforming growth factor beta binding

Biological Process

GO:0000302	response to reactive oxygen species
GO:0001822	kidney development
GO:0002244	hematopoietic progenitor cell differentiation
GO:0005975	carbohydrate metabolic process
GO:0006027	glycosaminoglycan catabolic process
GO:0009615	response to virus
GO:0010259	multicellular organismal aging
GO:0010764	negative regulation of fibroblast migration
GO:0019064	fusion of virus membrane with host plasma membrane
GO:0019087	transformation of host cell by virus
GO:0030203	glycosaminoglycan metabolic process
GO:0030212	hyaluronan metabolic process
GO:0030214	hyaluronan catabolic process
GO:0030308	negative regulation of cell growth
GO:0035810	positive regulation of urine volume
GO:0042117	monocyte activation
GO:0042307	positive regulation of protein import into nucleus
GO:0043407	negative regulation of MAP kinase activity
GO:0044281	small molecule metabolic process
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046677	response to antibiotic
GO:0046718	viral entry into host cell
GO:0048705	skeletal system morphogenesis
GO:0050729	positive regulation of inflammatory response
GO:0051216	cartilage development
GO:0051607	defense response to virus
GO:0051898	negative regulation of protein kinase B signaling
GO:0060586	multicellular organismal iron ion homeostasis
GO:0061099	negative regulation of protein tyrosine kinase activity
GO:0070295	renal water absorption
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071493	cellular response to UV-B
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:2000484	positive regulation of interleukin-8 secretion
GO:2000778	positive regulation of interleukin-6 secretion
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0009986	cell surface
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0016324	apical plasma membrane
GO:0030139	endocytic vesicle
GO:0031362	anchored component of external side of plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0045121	membrane raft
GO:0046658	anchored component of plasma membrane
GO:0048471	perinuclear region of cytoplasm