Version 5.4
Homo sapiens Gene: DOCK4
Summary
InnateDB Gene IDBG-36595.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOCK4
Gene Name dedicator of cytokinesis 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000128512
Encoded Proteins
IDBP-385320
dedicator of cytokinesis 4
IDBP-385322
dedicator of cytokinesis 4
IDBP-385325
dedicator of cytokinesis 4
IDBP-385326
dedicator of cytokinesis 4
IDBP-385327
dedicator of cytokinesis 4
IDBP-385328
dedicator of cytokinesis 4
IDBP-385329
dedicator of cytokinesis 4
IDBP-385330
dedicator of cytokinesis 4
IDBP-603070
dedicator of cytokinesis 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:111726110-112206411
Strand Reverse strand
Band q31.1
Transcripts
ENST00000423057 ENSP00000412834
ENST00000428084 ENSP00000410746
ENST00000437633 ENSP00000404179
ENST00000445943 ENSP00000397412
ENST00000428053 ENSP00000393486
ENST00000437129 ENSP00000406298
ENST00000450156 ENSP00000406468
ENST00000417165 ENSP00000403504
ENST00000486186
ENST00000494769
ENST00000494651 ENSP00000440944
ENST00000492436
ENST00000464338
ENST00000469898
ENST00000476846
ENST00000492532
ENST00000468571
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0030165 PDZ domain binding
GO:0030675 Rac GTPase activator activity
GO:0030971 receptor tyrosine kinase binding
GO:0048365 Rac GTPase binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0032855 positive regulation of Rac GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0060326 cell chemotaxis
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0032420 stereocilium
GO:0032421 stereocilium bundle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035954
View Gene Order
ENSBTAG00000021182
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.623477 Hs.654652
RefSeq NM_014705 XM_006716188 XM_006716189
HUGO
OMIM
CCDS CCDS47688
HPRD 07407
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca