Version 5.4
Homo sapiens Gene: ZFAT
Summary
InnateDB Gene IDBG-36602.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFAT
Gene Name zinc finger and AT hook domain containing
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000066827
Encoded Proteins
IDBP-36606
zinc finger and AT hook domain containing
IDBP-376731
zinc finger and AT hook domain containing
IDBP-480542
zinc finger and AT hook domain containing
IDBP-474493
zinc finger and AT hook domain containing
IDBP-485175
zinc finger and AT hook domain containing
IDBP-477205
zinc finger and AT hook domain containing
IDBP-479577
zinc finger and AT hook domain containing
IDBP-480209
zinc finger and AT hook domain containing
IDBP-483151
zinc finger and AT hook domain containing
IDBP-476726
zinc finger and AT hook domain containing
IDBP-482641
zinc finger and AT hook domain containing
IDBP-481989
zinc finger and AT hook domain containing
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:134477788-134713049
Strand Reverse strand
Band q24.22
Transcripts
ENST00000377838 ENSP00000367069
ENST00000429442 ENSP00000394501
ENST00000520356 ENSP00000427879
ENST00000520727 ENSP00000427831
ENST00000523924 ENSP00000429050
ENST00000523243 ENSP00000429930
ENST00000518408
ENST00000520214 ENSP00000428483
ENST00000521673 ENSP00000429600
ENST00000523399 ENSP00000429091
ENST00000522723
ENST00000517307
ENST00000519827 ENSP00000430924
ENST00000522974
ENST00000523040
ENST00000522257 ENSP00000429983
ENST00000518191 ENSP00000428192
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006351 transcription, DNA-templated
GO:0030097 hemopoiesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060712 spongiotrophoblast layer development
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022335
View Gene Order
ENSBTAG00000017731
Not yet available
Cross-References
SwissProt
TrEMBL E5RJT2
UniProt Splice Variant
Entrez Gene 57623
UniGene Hs.446172
RefSeq NM_001029939 NM_001167583 NM_001174157 NM_001174158 NM_001289394 NM_020863 XM_006716611
HUGO HGNC:19899
OMIM 610931
CCDS CCDS43768 CCDS47924 CCDS55275 CCDS55276
HPRD 11712
IMGT
EMBL AC015599 AC087045 AC135075
GenPept
RNA Seq Atlas 57623

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca