Version 5.4
Homo sapiens Gene: TUSC2
Summary
InnateDB Gene IDBG-36610.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TUSC2
Gene Name tumor suppressor candidate 2
Synonyms C3orf11; FUS1; PAP; PDAP2
Species Homo sapiens
Ensembl Gene ENSG00000114383
Encoded Proteins
IDBP-36612
tumor suppressor candidate 2
IDBP-378246
tumor suppressor candidate 2
IDBP-378247
tumor suppressor candidate 2
IDBP-378248
tumor suppressor candidate 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a highly conserved lung cancer candidate gene. No other information about this gene is currently available. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:50320027-50328251
Strand Reverse strand
Band p21.31
Transcripts
ENST00000232496 ENSP00000232496
ENST00000421918 ENSP00000409488
ENST00000454201 ENSP00000399199
ENST00000417867 ENSP00000394844
ENST00000462137
ENST00000463304
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 5 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001779 natural killer cell differentiation
GO:0006909 phagocytosis
GO:0006954 inflammatory response
GO:0007049 cell cycle
GO:0007267 cell-cell signaling
GO:0008283 cell proliferation
GO:0032618 interleukin-15 production
GO:0032700 negative regulation of interleukin-17 production
GO:0032733 positive regulation of interleukin-10 production
GO:0048469 cell maturation
GO:0050829 defense response to Gram-negative bacterium
GO:0051881 regulation of mitochondrial membrane potential
GO:0052567 response to defense-related host reactive oxygen species production
GO:0070945 neutrophil mediated killing of gram-negative bacterium
GO:0071609 chemokine (C-C motif) ligand 5 production
GO:2000377 regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000010054
View Gene Order
ENSBTAG00000020962
Not yet available
Cross-References
SwissProt
TrEMBL F2Z2A9
UniProt Splice Variant
Entrez Gene 11334
UniGene Hs.517981
RefSeq NM_007275
HUGO HGNC:17034
OMIM 607052
CCDS CCDS2819
HPRD 06134
IMGT
EMBL AC002455
GenPept
RNA Seq Atlas 11334

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca