InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KIF18A

Summary

InnateDB Gene

IDBG-36958.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF18A

Gene Name

kinesin family member 18A

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000121621

Encoded Proteins

IDBP-36960

kinesin family member 18A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:28020620-28108308

Strand

Reverse strand

Band

p14.1

Transcripts

ENST00000263181	ENSP00000263181
ENST00000533466
ENST00000531047
ENST00000526288

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0008574	plus-end-directed microtubule motor activity
GO:0043130	ubiquitin binding
GO:0051010	microtubule plus-end binding
GO:0070463	tubulin-dependent ATPase activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0006200	ATP catabolic process
GO:0007018	microtubule-based movement
GO:0007019	microtubule depolymerization
GO:0007080	mitotic metaphase plate congression
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0015031	protein transport
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005828	kinetochore microtubule
GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0005901	caveola
GO:0015630	microtubule cytoskeleton