Version 5.4
Homo sapiens Gene: FGF2
Summary
InnateDB Gene IDBG-37039.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGF2
Gene Name fibroblast growth factor 2 (basic)
Synonyms BFGF; FGF-2; FGFB; HBGF-2
Species Homo sapiens
Ensembl Gene ENSG00000138685
Encoded Proteins
IDBP-37041
fibroblast growth factor 2 (basic)
IDBP-806475
fibroblast growth factor 2 (basic)
IDBP-806478
fibroblast growth factor 2 (basic)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:122826708-122898236
Strand Forward strand
Band q28.1
Transcripts
ENST00000264498 ENSP00000264498
ENST00000608478 ENSP00000477134
ENST00000614010 ENSP00000478620
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 31 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005104 fibroblast growth factor receptor binding
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0042056 chemoattractant activity
Biological Process
GO:0000186 activation of MAPKK activity
GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001759 organ induction
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007399 nervous system development
GO:0007568 aging
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009792 embryo development ending in birth or egg hatching
GO:0009887 organ morphogenesis
GO:0010001 glial cell differentiation
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010764 negative regulation of fibroblast migration
GO:0010863 positive regulation of phospholipase C activity
GO:0021762 substantia nigra development
GO:0021940 positive regulation of cerebellar granule cell precursor proliferation
GO:0030198 extracellular matrix organization
GO:0030214 hyaluronan catabolic process
GO:0030324 lung development
GO:0032958 inositol phosphate biosynthetic process
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042060 wound healing
GO:0042660 positive regulation of cell fate specification
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 innate immune response
GO:0045597 positive regulation of cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046668 regulation of retinal cell programmed cell death
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048598 embryonic morphogenesis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048678 response to axon injury
GO:0048864 stem cell development
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050918 positive chemotaxis
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051726 regulation of cell cycle
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060128 corticotropin hormone secreting cell differentiation
GO:0060129 thyroid-stimulating hormone-secreting cell differentiation
GO:0060548 negative regulation of cell death
GO:0060591 chondroblast differentiation
GO:0060644 mammary gland epithelial cell differentiation
GO:0060978 angiogenesis involved in coronary vascular morphogenesis
GO:0061045 negative regulation of wound healing
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037225
View Gene Order
ENSBTAG00000005691
Not yet available
Pathways
NETPATH
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_111184
Negative regulation of FGFR signaling pathway
REACT_21310
Phospholipase C-mediated cascade pathway
REACT_21374
SHC-mediated cascade pathway
REACT_21270
PI-3K cascade pathway
REACT_21247
FRS2-mediated cascade pathway
REACT_9413
FGFR2c ligand binding and activation pathway
REACT_9510
FGFR3c ligand binding and activation pathway
REACT_9515
FGFR1c ligand binding and activation pathway
REACT_9400
FGFR1b ligand binding and activation pathway
REACT_9452
FGFR4 ligand binding and activation pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_120863
Activated point mutants of FGFR2 pathway
REACT_121153
Signaling by activated point mutants of FGFR1 pathway
REACT_121337
Signaling by activated point mutants of FGFR3 pathway
REACT_121398
Signaling by FGFR mutants pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_121249
Signaling by FGFR3 mutants pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_200812
Transcriptional regulation of pluripotent stem cells pathway
REACT_118779
Extracellular matrix organization pathway
REACT_200759
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163942
Syndecan interactions pathway
REACT_120999
Signaling by FGFR1 mutants pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
REACT_9439
FGFR3 ligand binding and activation pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_762
IRS-related events pathway
REACT_121155
Signaling by FGFR2 mutants pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_9390
FGFR2 ligand binding and activation pathway
REACT_9396
FGFR ligand binding and activation pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_9483
FGFR1 ligand binding and activation pathway
REACT_116125
Disease pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04010
MAPK signaling pathway pathway
hsa05218
Melanoma pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
FGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
avb3_integrin_pathway
Integrins in angiogenesis
glypican_1pathway
Glypican 1 network
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
syndecan_4_pathway
Syndecan-4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.284244 Hs.682474 Hs.690124
RefSeq NM_002006
HUGO
OMIM
CCDS CCDS34059
HPRD 00622
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca