InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KCNA4

Summary

InnateDB Gene

IDBG-37083.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNA4

Gene Name

potassium voltage-gated channel, shaker-related subfamily, member 4

Synonyms

HBK4; HK1; HPCN2; HUKII; KCNA4L; KCNA8; KV1.4; PCN2

Species

Homo sapiens

Ensembl Gene

ENSG00000182255

Encoded Proteins

IDBP-37085

potassium voltage-gated channel, shaker-related subfamily, member 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.[provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:30009741-30017023

Strand

Reverse strand

Band

p14.1

Transcripts

ENST00000328224	ENSP00000328511
ENST00000526518

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005515	protein binding
GO:0030955	potassium ion binding

Biological Process

GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0034765	regulation of ion transmembrane transport
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000042604

View Gene Order

ENSBTAG00000020793

Not yet available

Pathways

NETPATH

REACTOME

REACT_75770

Voltage gated Potassium channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.458267 Hs.592002

RefSeq

NM_002233

HUGO

OMIM

CCDS

CCDS41629

HPRD

01444

IMGT

EMBL

GenPept

RNA Seq Atlas