InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MDFIC

Summary

InnateDB Gene

IDBG-37093.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MDFIC

Gene Name

MyoD family inhibitor domain containing

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000135272

Encoded Proteins

IDBP-37095

MyoD family inhibitor domain containing

IDBP-243520

MyoD family inhibitor domain containing

IDBP-385523

MyoD family inhibitor domain containing

IDBP-385524

MyoD family inhibitor domain containing

IDBP-385525

MyoD family inhibitor domain containing

IDBP-385526

MyoD family inhibitor domain containing

IDBP-477736

MyoD family inhibitor domain containing

IDBP-807300

MyoD family inhibitor domain containing

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:114922154-115019916

Strand

Forward strand

Band

q31.1

Transcripts

ENST00000257724	ENSP00000257724
ENST00000393486	ENSP00000377126
ENST00000448022	ENSP00000412153
ENST00000423503	ENSP00000401623
ENST00000431629	ENSP00000416668
ENST00000427207	ENSP00000392098
ENST00000498196	ENSP00000418337
ENST00000614186	ENSP00000484656

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0030332	cyclin binding
GO:0030515	snoRNA binding
GO:0030957	Tat protein binding

Biological Process

GO:0001522	pseudouridine synthesis
GO:0006351	transcription, DNA-templated
GO:0007257	activation of JUN kinase activity
GO:0016032	viral process
GO:0030111	regulation of Wnt signaling pathway
GO:0042254	ribosome biogenesis
GO:0042308	negative regulation of protein import into nucleus
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050434	positive regulation of viral transcription

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0072588	box H/ACA RNP complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000041390

View Gene Order

ENSBTAG00000021543

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

betacatenin_nuc_pathway

Regulation of nuclear beta catenin signaling and target gene transcription

Cross-References

SwissProt

Q9P1T7

TrEMBL

C9J784

UniProt Splice Variant

Entrez Gene

29969

UniGene

Hs.427236 Hs.601381 Hs.741413

RefSeq

NM_001166345 NM_199072

HUGO

HGNC:28870

OMIM

614511

CCDS

CCDS55155 CCDS34737

HPRD

17103

IMGT

EMBL

AC017003 AF054589 AY196485

GenPept

AAF36998 AAF36999 AAP33842

RNA Seq Atlas

29969