InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EIF2C2

Summary

InnateDB Gene

IDBG-37096.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF2C2

Gene Name

eukaryotic translation initiation factor 2C, 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000123908

Encoded Proteins

IDBP-37100

eukaryotic translation initiation factor 2C, 2

IDBP-474041

eukaryotic translation initiation factor 2C, 2

IDBP-478623

eukaryotic translation initiation factor 2C, 2

IDBP-482990

eukaryotic translation initiation factor 2C, 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:140531165-140635619

Strand

Reverse strand

Band

q24.3

Transcripts

ENST00000220592	ENSP00000220592
ENST00000519980	ENSP00000430176
ENST00000523609	ENSP00000430164
ENST00000520628
ENST00000520412
ENST00000519347
ENST00000521325
ENST00000517293
ENST00000524328	ENSP00000431056
ENST00000518019

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 135 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	135 [view]
Protein-Protein	127 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000340	RNA 7-methylguanosine cap binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003743	translation initiation factor activity
GO:0004521	endoribonuclease activity
GO:0005515	protein binding
GO:0035197	siRNA binding
GO:0035198	miRNA binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding
GO:0070551	endoribonuclease activity, cleaving siRNA-paired mRNA

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006379	mRNA cleavage
GO:0006412	translation
GO:0006413	translational initiation
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009791	post-embryonic development
GO:0010467	gene expression
GO:0031047	gene silencing by RNA
GO:0031054	pre-miRNA processing
GO:0035278	negative regulation of translation involved in gene silencing by miRNA
GO:0035279	mRNA cleavage involved in gene silencing by miRNA
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0045947	negative regulation of translational initiation
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005844	polysome
GO:0005845	mRNA cap binding complex
GO:0016020	membrane
GO:0016442	RISC complex
GO:0030529	ribonucleoprotein complex
GO:0035068	micro-ribonucleoprotein complex