InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACD

Summary

InnateDB Gene

IDBG-37133.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACD

Gene Name

adrenocortical dysplasia homolog (mouse)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000102977

Encoded Proteins

IDBP-37135

adrenocortical dysplasia homolog (mouse)

IDBP-242637

adrenocortical dysplasia homolog (mouse)

IDBP-809698

adrenocortical dysplasia homolog (mouse)

IDBP-809701

adrenocortical dysplasia homolog (mouse)

IDBP-809705

adrenocortical dysplasia homolog (mouse)

IDBP-809707

adrenocortical dysplasia homolog (mouse)

IDBP-809709

adrenocortical dysplasia homolog (mouse)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:67657512-67660815

Strand

Reverse strand

Band

q22.1

Transcripts

ENST00000219251	ENSP00000219251
ENST00000393919	ENSP00000377496
ENST00000620761	ENSP00000478084
ENST00000602382	ENSP00000473313
ENST00000602656
ENST00000602622
ENST00000602320	ENSP00000473679
ENST00000602860
ENST00000602850	ENSP00000473595
ENST00000602945
ENST00000602519
ENST00000602423
ENST00000602780
ENST00000602821
ENST00000620338	ENSP00000483117

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	74 [view]
Protein-Protein	73 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0070182	DNA polymerase binding

Biological Process

GO:0000723	telomere maintenance
GO:0001501	skeletal system development
GO:0001655	urogenital system development
GO:0006886	intracellular protein transport
GO:0016233	telomere capping
GO:0030326	embryonic limb morphogenesis
GO:0031848	protection from non-homologous end joining at telomere
GO:0032202	telomere assembly
GO:0032211	negative regulation of telomere maintenance via telomerase
GO:0035282	segmentation
GO:0051973	positive regulation of telomerase activity
GO:0060381	positive regulation of single-stranded telomeric DNA binding
GO:0070198	protein localization to chromosome, telomeric region