InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: JAK3

Summary

InnateDB Gene

IDBG-37201.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

JAK3

Gene Name

Janus kinase 3

Synonyms

JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK

Species

Homo sapiens

Ensembl Gene

ENSG00000105639

Encoded Proteins

IDBP-375657

Janus kinase 3

IDBP-598560

Janus kinase 3

IDBP-601697

Janus kinase 3

IDBP-809958

Janus kinase 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 14976041

JAK3 is a primary response gene for IL6 in macrophage differentiation and ectopic overexpression of JAK3 accelerates monocytic differentiation of normal mouse bone marrow cells stimulated with cytokines.

PMID 22359619

JAK3 inhibition is sufficient to counteract lung injury and protect immunocytes from hypercytokinemia following challenge with avian influenza H5N1 hemagglutinin.

InnateDB Annotation from Orthologs

Summary

PMID 22359619

[Mus musculus] Jak3 inhibition is sufficient to counteract lung injury and protect immunocytes from hypercytokinemia following challenge with avian influenza H5N1 hemagglutinin.

Entrez Gene

Summary

The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:17824780-17848071

Strand

Reverse strand

Band

p13.11

Transcripts

ENST00000458235	ENSP00000391676
ENST00000527031
ENST00000527670	ENSP00000432511
ENST00000534444	ENSP00000436421
ENST00000526008
ENST00000528705
ENST00000528293
ENST00000613342	ENSP00000481954

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	56 [view]
Protein-Protein	56 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019903	protein phosphatase binding

Biological Process

GO:0002731	negative regulation of dendritic cell cytokine production
GO:0006468	protein phosphorylation
GO:0007167	enzyme linked receptor protein signaling pathway
GO:0007260	tyrosine phosphorylation of STAT protein
GO:0007262	STAT protein import into nucleus
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030183	B cell differentiation
GO:0032693	negative regulation of interleukin-10 production
GO:0032695	negative regulation of interleukin-12 production
GO:0035556	intracellular signal transduction
GO:0035771	interleukin-4-mediated signaling pathway
GO:0043029	T cell homeostasis
GO:0045087	innate immune response (InnateDB)
GO:0045221	negative regulation of FasL biosynthetic process
GO:0045626	negative regulation of T-helper 1 cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050868	negative regulation of T cell activation
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070232	regulation of T cell apoptotic process
GO:0070244	negative regulation of thymocyte apoptotic process
GO:0070669	response to interleukin-2
GO:0070670	response to interleukin-4
GO:0070672	response to interleukin-15
GO:0071104	response to interleukin-9
GO:2000670	positive regulation of dendritic cell apoptotic process
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand