InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAPKAPK3

Summary

InnateDB Gene

IDBG-37235.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPKAPK3

Gene Name

mitogen-activated protein kinase-activated protein kinase 3

Synonyms

3PK; MAPKAP-K3; MAPKAP3; MAPKAPK-3; MK-3

Species

Homo sapiens

Ensembl Gene

ENSG00000114738

Encoded Proteins

IDBP-37237

mitogen-activated protein kinase-activated protein kinase 3

IDBP-378627

mitogen-activated protein kinase-activated protein kinase 3

IDBP-378630

mitogen-activated protein kinase-activated protein kinase 3

IDBP-378632

mitogen-activated protein kinase-activated protein kinase 3

IDBP-378635

mitogen-activated protein kinase-activated protein kinase 3

IDBP-813792

mitogen-activated protein kinase-activated protein kinase 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:50611520-50649297

Strand

Forward strand

Band

p21.2

Transcripts

ENST00000357955	ENSP00000350639
ENST00000446044	ENSP00000396467
ENST00000430409	ENSP00000410970
ENST00000457064	ENSP00000402045
ENST00000451680	ENSP00000394894
ENST00000486712
ENST00000497283
ENST00000621469	ENSP00000478922

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004708	MAP kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0000187	activation of MAPK activity
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006468	protein phosphorylation
GO:0006950	response to stress
GO:0007165	signal transduction
GO:0007265	Ras protein signal transduction
GO:0009103	lipopolysaccharide biosynthetic process
GO:0018105	peptidyl-serine phosphorylation
GO:0032496	response to lipopolysaccharide
GO:0034097	response to cytokine
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0044351	macropinocytosis
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051403	stress-activated MAPK cascade