Version 5.4
Homo sapiens Gene: HOXC13
Summary
InnateDB Gene IDBG-37255.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOXC13
Gene Name homeobox C13
Synonyms ECTD9; HOX3; HOX3G
Species Homo sapiens
Ensembl Gene ENSG00000123364
Encoded Proteins
IDBP-37257
homeobox C13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:53938765-53946544
Strand Forward strand
Band q13.13
Transcripts
ENST00000243056 ENSP00000243056
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001942 hair follicle development
GO:0006351 transcription, DNA-templated
GO:0009653 anatomical structure morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0035878 nail development
GO:0043587 tongue morphogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001655
View Gene Order
ENSBTAG00000000923
Not yet available
Cross-References
SwissProt P31276
TrEMBL Q6LAM3
UniProt Splice Variant
Entrez Gene 3229
UniGene Hs.118608
RefSeq NM_017410
HUGO HGNC:5125
OMIM 142976
CCDS CCDS8865
HPRD
IMGT
EMBL AF255676 AF263466 AK024027 BC090850 BT009908 X99679
GenPept AAF67760 AAF73439 AAH90850 AAP88910 BAB14786 CAA67995
RNA Seq Atlas 3229

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca