Version 5.4
Homo sapiens Gene: ONECUT2
Summary
InnateDB Gene IDBG-3735.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ONECUT2
Gene Name one cut homeobox 2
Synonyms OC-2; OC2
Species Homo sapiens
Ensembl Gene ENSG00000119547
Encoded Proteins
IDBP-479265
one cut homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:57435685-57491297
Strand Forward strand
Band q21.31
Transcripts
ENST00000491143 ENSP00000419185
ENST00000481727
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0001889 liver development
GO:0001952 regulation of cell-matrix adhesion
GO:0002064 epithelial cell development
GO:0006351 transcription, DNA-templated
GO:0009653 anatomical structure morphogenesis
GO:0009887 organ morphogenesis
GO:0030335 positive regulation of cell migration
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031016 pancreas development
GO:0031018 endocrine pancreas development
GO:0042384 cilium assembly
GO:0045165 cell fate commitment
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048935 peripheral nervous system neuron development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000045991
View Gene Order
ENSBTAG00000022819
Not yet available
Cross-References
SwissProt O95948
TrEMBL
UniProt Splice Variant
Entrez Gene 9480
UniGene Hs.194725 Hs.437036 Hs.587951
RefSeq NM_004852
HUGO HGNC:8139
OMIM 604894
CCDS CCDS42440
HPRD 05354
IMGT
EMBL AC090340 Y18198
GenPept CAB38253
RNA Seq Atlas 9480

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca