InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPL23A

Summary

InnateDB Gene

IDBG-37482.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPL23A

Gene Name

ribosomal protein L23a

Synonyms

L23A; MDA20

Species

Homo sapiens

Ensembl Gene

ENSG00000198242

Encoded Proteins

IDBP-37484

ribosomal protein L23a

IDBP-239976

ribosomal protein L23a

IDBP-764393

IDBP-373955

ribosomal protein L23a

IDBP-763977

IDBP-758641

IDBP-764130

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:28719393-28724359

Strand

Forward strand

Band

q11.2

Transcripts

ENST00000355731	ENSP00000347969
ENST00000394938	ENSP00000378396
ENST00000394935	ENSP00000468402
ENST00000422514	ENSP00000389103
ENST00000496182	ENSP00000468172
ENST00000472628	ENSP00000466425
ENST00000582736
ENST00000580755
ENST00000578181	ENSP00000465342

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 153 experimentally validated interaction(s) in this database.

Experimentally validated
Total	153 [view]
Protein-Protein	152 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019843	rRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0008283	cell proliferation
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0031932	TORC2 complex
GO:0070062	extracellular vesicular exosome