Version 5.4
Homo sapiens Gene: KCNN2
Summary
InnateDB Gene IDBG-37535.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNN2
Gene Name potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Synonyms hSK2; KCa2.2; SK2; SKCa 2; SKCA2
Species Homo sapiens
Ensembl Gene ENSG00000080709
Encoded Proteins
IDBP-37539
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
IDBP-484864
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
IDBP-483403
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
IDBP-483989
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
IDBP-809373
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:114360945-114496640
Strand Forward strand
Band q22.3
Transcripts
ENST00000264773 ENSP00000264773
ENST00000512097 ENSP00000427120
ENST00000507750
ENST00000503706 ENSP00000421439
ENST00000505491 ENSP00000421095
ENST00000506812
ENST00000610748 ENSP00000483124
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 9 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005516 calmodulin binding
GO:0015269 calcium-activated potassium channel activity
GO:0016286 small conductance calcium-activated potassium channel activity
GO:0042803 protein homodimerization activity
GO:0051393 alpha-actinin binding
Biological Process
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0071805 potassium ion transmembrane transport
GO:1901379 regulation of potassium ion transmembrane transport
Cellular Component
GO:0005790 smooth endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054477
View Gene Order
ENSBTAG00000011076
Not yet available
Pathways
NETPATH
REACTOME
REACT_75896
Ca2+ activated K+ channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
KEGG
hsa04976
Bile secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.606380 Hs.98280
RefSeq NM_001278204 NM_021614 NM_170775 XM_006714613
HUGO
OMIM
CCDS CCDS4114 CCDS43352
HPRD 09323
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca