Version 5.4
Homo sapiens Gene: HNRNPA1
Summary
InnateDB Gene IDBG-37588.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HNRNPA1
Gene Name heterogeneous nuclear ribonucleoprotein A1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135486
Encoded Proteins
IDBP-37590
heterogeneous nuclear ribonucleoprotein A1
IDBP-37592
heterogeneous nuclear ribonucleoprotein A1
IDBP-595477
heterogeneous nuclear ribonucleoprotein A1
IDBP-590404
heterogeneous nuclear ribonucleoprotein A1
IDBP-587508
heterogeneous nuclear ribonucleoprotein A1
IDBP-596777
heterogeneous nuclear ribonucleoprotein A1
IDBP-587684
heterogeneous nuclear ribonucleoprotein A1
IDBP-585683
heterogeneous nuclear ribonucleoprotein A1
IDBP-588540
heterogeneous nuclear ribonucleoprotein A1
IDBP-603205
heterogeneous nuclear ribonucleoprotein A1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:54280193-54287088
Strand Forward strand
Band q13.13
Transcripts
ENST00000340913 ENSP00000341826
ENST00000330752 ENSP00000333504
ENST00000546500 ENSP00000448617
ENST00000547708 ENSP00000448229
ENST00000547566 ENSP00000449913
ENST00000547870
ENST00000551702 ENSP00000448117
ENST00000547276 ENSP00000447260
ENST00000548688 ENSP00000447782
ENST00000550994 ENSP00000448917
ENST00000550482 ENSP00000446486
ENST00000551679
ENST00000551665
ENST00000551803
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 315 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 315 [view]
Protein-Protein 304 [view]
Protein-DNA 5 [view]
Protein-RNA 5 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0003727 single-stranded RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000380 alternative mRNA splicing, via spliceosome
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0006405 RNA export from nucleus
GO:0008219 cell death
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0016032 viral process
GO:0051028 mRNA transport
GO:0051168 nuclear export
GO:0051170 nuclear import
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0045111 intermediate filament cytoskeleton
GO:0070062 extracellular vesicular exosome
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000046434
View Gene Order
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_18
IL6 pathway
REACTOME
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
ar_pathway
Coregulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.546261 Hs.606134 Hs.619436 Hs.657333 Hs.660908 Hs.661139 Hs.715546 Hs.735600
RefSeq NM_002136 NM_031157 XM_005268826
HUGO
OMIM
CCDS CCDS41793 CCDS44909
HPRD 01242
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca