InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ITGA5

Summary

InnateDB Gene

IDBG-37894.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA5

Gene Name

integrin, alpha 5 (fibronectin receptor, alpha polypeptide)

Synonyms

CD49e; FNRA; VLA5A

Species

Homo sapiens

Ensembl Gene

ENSG00000161638

Encoded Proteins

IDBP-37896

integrin, alpha 5 (fibronectin receptor, alpha polypeptide)

IDBP-376899

integrin, alpha 5 (fibronectin receptor, alpha polypeptide)

IDBP-589141

integrin, alpha 5 (fibronectin receptor, alpha polypeptide)

IDBP-599701

integrin, alpha 5 (fibronectin receptor, alpha polypeptide)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:54395261-54419460

Strand

Reverse strand

Band

q13.13

Transcripts

ENST00000293379	ENSP00000293379
ENST00000435631	ENSP00000405865
ENST00000552564
ENST00000547197	ENSP00000450267
ENST00000549601
ENST00000552431
ENST00000552387
ENST00000552583
ENST00000551564
ENST00000550141
ENST00000551861
ENST00000553071	ENSP00000447347
ENST00000547744

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	42 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005154	epidermal growth factor receptor binding
GO:0005161	platelet-derived growth factor receptor binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0043184	vascular endothelial growth factor receptor 2 binding
GO:0046872	metal ion binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0001525	angiogenesis
GO:0007044	cell-substrate junction assembly
GO:0007155	cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0007613	memory
GO:0010811	positive regulation of cell-substrate adhesion
GO:0016032	viral process
GO:0030198	extracellular matrix organization
GO:0030335	positive regulation of cell migration
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031589	cell-substrate adhesion
GO:0033631	cell-cell adhesion mediated by integrin
GO:0035313	wound healing, spreading of epidermal cells
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050900	leukocyte migration
GO:2000811	negative regulation of anoikis

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005925	focal adhesion
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0032587	ruffle membrane
GO:0045202	synapse
GO:0071062	alphav-beta3 integrin-vitronectin complex