InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: JUND

Summary

InnateDB Gene

IDBG-37954.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

JUND

Gene Name

jun D proto-oncogene

Synonyms

AP-1

Species

Homo sapiens

Ensembl Gene

ENSG00000130522

Encoded Proteins

IDBP-37956

jun D proto-oncogene

IDBP-811111

jun D proto-oncogene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternate translation initiation site usage results in the production of different isoforms. [provided by RefSeq, Jul 2008]
The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:18279760-18281622

Strand

Reverse strand

Band

p13.11

Transcripts

ENST00000252818	ENSP00000252818
ENST00000600972	ENSP00000475153

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	68 [view]
Protein-Protein	58 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0019899	enzyme binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0002076	osteoblast development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007568	aging
GO:0007623	circadian rhythm
GO:0009416	response to light stimulus
GO:0009612	response to mechanical stimulus
GO:0014070	response to organic cyclic compound
GO:0032496	response to lipopolysaccharide
GO:0043434	response to peptide hormone
GO:0045669	positive regulation of osteoblast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071277	cellular response to calcium ion

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000071076

View Gene Order

Pathways

NETPATH

NetPath_4

EGFR1 pathway

NetPath_7

TGF_beta_Receptor pathway

NetPath_114

Oncostatin_M pathway

REACTOME

KEGG

hsa04010

MAPK signaling pathway pathway

hsa04380

Osteoclast differentiation pathway

INOH

PID NCI

fra_pathway

Validated transcriptional targets of AP1 family members Fra1 and Fra2

atf2_pathway

ATF-2 transcription factor network

ap1_pathway

AP-1 transcription factor network

pdgfrbpathway

PDGFR-beta signaling pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.2780

RefSeq

NM_001286968 NM_005354

HUGO

OMIM

CCDS

CCDS32959

HPRD

01304

IMGT

EMBL

GenPept

RNA Seq Atlas