InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NFATC3

Summary

InnateDB Gene

IDBG-38028.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFATC3

Gene Name

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

Synonyms

NFAT4; NFATX

Species

Homo sapiens

Ensembl Gene

ENSG00000072736

Encoded Proteins

IDBP-38032

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

IDBP-38034

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

IDBP-38036

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

IDBP-596389

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

IDBP-751781

IDBP-748449

IDBP-752434

IDBP-749713

IDBP-752333

IDBP-750331

IDBP-752945

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21726630

NFATC3 is a transcription factor required for the regulation of the Toll-like receptor-activated innate inflammatory response in monocytes/macrophages. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21726630

[Mus musculus] Nfatc3 is a transcription factor required for the regulation of the Toll-like receptor-activated innate inflammatory response in monocytes/macrophages.

Entrez Gene

Summary

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:68084751-68229259

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000379165
ENST00000329524	ENSP00000331324
ENST00000349223	ENSP00000264008
ENST00000346183	ENSP00000300659
ENST00000553077
ENST00000549350
ENST00000539828	ENSP00000445670
ENST00000535127
ENST00000563319
ENST00000566301
ENST00000562171	ENSP00000456307
ENST00000563796
ENST00000562926	ENSP00000456120
ENST00000565750	ENSP00000457441
ENST00000568466	ENSP00000454451
ENST00000575270	ENSP00000460533
ENST00000563288
ENST00000561714	ENSP00000455113
ENST00000566893
ENST00000569766
ENST00000570212	ENSP00000456379
ENST00000567152

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	8 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006954	inflammatory response
GO:0007507	heart development
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045333	cellular respiration
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051145	smooth muscle cell differentiation
GO:0055001	muscle cell development
GO:0071277	cellular response to calcium ion
GO:0071285	cellular response to lithium ion

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031902

View Gene Order

ENSBTAG00000004368

Not yet available

Pathways

NETPATH

NetPath_12

BCR pathway

REACTOME

REACT_6802

Innate Immune System pathway

REACT_163936

Fc epsilon receptor (FCERI) signaling pathway

REACT_6900

Immune System pathway

REACT_163834

FCERI mediated Ca+2 mobilization pathway

KEGG

hsa04310

Wnt signaling pathway pathway

hsa04010

MAPK signaling pathway pathway

hsa04360

Axon guidance pathway

hsa04662

B cell receptor signaling pathway pathway

hsa04660

T cell receptor signaling pathway pathway

INOH

PID NCI

nfat_3pathway

Role of Calcineurin-dependent NFAT signaling in lymphocytes

foxm1pathway

FOXM1 transcription factor network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.436585

RefSeq

NM_004555 NM_173163 NM_173165

HUGO

OMIM

CCDS

CCDS10860 CCDS10861 CCDS10862

HPRD

04077

IMGT

EMBL

GenPept

RNA Seq Atlas