InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ING3

Summary

InnateDB Gene

IDBG-38115.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ING3

Gene Name

inhibitor of growth family, member 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000071243

Encoded Proteins

IDBP-38117

inhibitor of growth family, member 3

IDBP-38121

inhibitor of growth family, member 3

IDBP-385803

inhibitor of growth family, member 3

IDBP-385804

inhibitor of growth family, member 3

IDBP-385805

inhibitor of growth family, member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:120950749-120977216

Strand

Forward strand

Band

q31.31

Transcripts

ENST00000315870	ENSP00000320566
ENST00000339121	ENSP00000341697
ENST00000427726	ENSP00000410406
ENST00000445699	ENSP00000395719
ENST00000431467	ENSP00000388506
ENST00000497502

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	28 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0035064	methylated histone binding

Biological Process

GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016568	chromatin modification
GO:0040008	regulation of growth
GO:0043065	positive regulation of apoptotic process
GO:0043967	histone H4 acetylation
GO:0043968	histone H2A acetylation

Cellular Component

GO:0000812	Swr1 complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0032777	Piccolo NuA4 histone acetyltransferase complex
GO:0035267	NuA4 histone acetyltransferase complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029670

View Gene Order

ENSBTAG00000016332

Not yet available

Pathways

NETPATH

REACTOME

REACT_172610

HATs acetylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.489811 Hs.606997 Hs.660438

RefSeq

NM_019071 NM_198267

HUGO

OMIM

CCDS

CCDS35497 CCDS5778

HPRD

06321

IMGT

EMBL

GenPept

RNA Seq Atlas