Version 5.4
Homo sapiens Gene: SEMA6A
Summary
InnateDB Gene IDBG-38142.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEMA6A
Gene Name sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000092421
Encoded Proteins
IDBP-38144
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
IDBP-38148
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
IDBP-481748
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
IDBP-482110
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
IDBP-478700
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
IDBP-482009
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
IDBP-481796
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
IDBP-474999
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:116443616-116574934
Strand Reverse strand
Band q23.1
Transcripts
ENST00000343348 ENSP00000345512
ENST00000257414 ENSP00000257414
ENST00000515129 ENSP00000422275
ENST00000513137 ENSP00000422997
ENST00000503865 ENSP00000425364
ENST00000510263 ENSP00000424388
ENST00000506114
ENST00000514316
ENST00000503402
ENST00000510024
ENST00000502996
ENST00000503962
ENST00000515009 ENSP00000421935
ENST00000509665 ENSP00000425553
ENST00000512156
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0030215 semaphorin receptor binding
Biological Process
GO:0001764 neuron migration
GO:0006915 apoptotic process
GO:0007010 cytoskeleton organization
GO:0007166 cell surface receptor signaling pathway
GO:0007275 multicellular organismal development
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0009887 organ morphogenesis
GO:0051642 centrosome localization
GO:0071526 semaphorin-plexin signaling pathway
GO:2001224 positive regulation of neuron migration
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019647
View Gene Order
ENSBTAG00000020489
Not yet available
Pathways
NETPATH
REACTOME
REACT_19200
Other semaphorin interactions pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt Q9H2E6
TrEMBL D6RAG9 D6RCR0 Q96SW4 Q96SY4
UniProt Splice Variant
Entrez Gene 57556
UniGene Hs.156967 Hs.624096
RefSeq NM_020796 NM_001300780 XM_005272041
HUGO HGNC:10738
OMIM 605885
CCDS CCDS47256 CCDS75288
HPRD 06906
IMGT
EMBL AB037789 AC008524 AC010296 AC027304 AF279656 AK027471 AK027501
GenPept AAG29378 BAA92606 BAB55136 BAB55158
RNA Seq Atlas 57556

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca