Version 5.4
Homo sapiens Gene: MPV17
Summary
InnateDB Gene IDBG-38263.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MPV17
Gene Name MpV17 mitochondrial inner membrane protein
Synonyms MTDPS6; SYM1
Species Homo sapiens
Ensembl Gene ENSG00000115204
Encoded Proteins
IDBP-1963
MpV17 mitochondrial inner membrane protein
IDBP-38267
MpV17 mitochondrial inner membrane protein
IDBP-38269
MpV17 mitochondrial inner membrane protein
IDBP-231610
MpV17 mitochondrial inner membrane protein
IDBP-294521
MpV17 mitochondrial inner membrane protein
IDBP-294518
MpV17 mitochondrial inner membrane protein
IDBP-294520
MpV17 mitochondrial inner membrane protein
IDBP-294514
MpV17 mitochondrial inner membrane protein
IDBP-294506
MpV17 mitochondrial inner membrane protein
IDBP-369205
MpV17 mitochondrial inner membrane protein
IDBP-369211
MpV17 mitochondrial inner membrane protein
IDBP-369215
MpV17 mitochondrial inner membrane protein
IDBP-369221
MpV17 mitochondrial inner membrane protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial inner membrane protein that is implicated in the metabolism of reactive oxygen species. Mutations in this gene have been associated with the hepatocerebral form of mitochondrial DNA depletion syndrome (MDDS). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:27309492-27325680
Strand Reverse strand
Band p23.3
Transcripts
ENST00000357186 ENSP00000349713
ENST00000380044 ENSP00000369383
ENST00000233545 ENSP00000233545
ENST00000399052 ENSP00000382006
ENST00000402310 ENSP00000383955
ENST00000405983 ENSP00000384586
ENST00000405076 ENSP00000385175
ENST00000403262 ENSP00000385671
ENST00000402722 ENSP00000386000
ENST00000426513 ENSP00000403824
ENST00000430991 ENSP00000406441
ENST00000415514 ENSP00000388043
ENST00000428910 ENSP00000405235
ENST00000475085
ENST00000486898
ENST00000494436
ENST00000620797
ENST00000621183
ENST00000616707
ENST00000617583
ENST00000621470
ENST00000622003
ENST00000616446
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
Experimentally validated
Total 48 [view]
Protein-Protein 47 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0032836 glomerular basement membrane development
GO:0034614 cellular response to reactive oxygen species
GO:0042592 homeostatic process
GO:0048839 inner ear development
GO:0072593 reactive oxygen species metabolic process
GO:2000377 regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005777 peroxisome
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000090262
View Gene Order
ENSBTAG00000018269
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9J473
UniProt Splice Variant
Entrez Gene 4358
UniGene Hs.75659
RefSeq NM_002437 XM_005264326 XM_005264327
HUGO HGNC:7224
OMIM 137960
CCDS CCDS1748
HPRD 08847
IMGT
EMBL AC013413
GenPept
RNA Seq Atlas 4358

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca