Version 5.4
Homo sapiens Gene: FKBP8
Summary
InnateDB Gene IDBG-38336.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FKBP8
Gene Name FK506 binding protein 8, 38kDa
Synonyms FKBP38; FKBPr38
Species Homo sapiens
Ensembl Gene ENSG00000105701
Encoded Proteins
IDBP-38338
FK506 binding protein 8, 38kDa
IDBP-590112
FK506 binding protein 8, 38kDa
IDBP-764883
IDBP-764151
IDBP-765217
IDBP-762286
IDBP-808115
FK506 binding protein 8, 38kDa
IDBP-766072
IDBP-763384
IDBP-764678
IDBP-808114
FK506 binding protein 8, 38kDa
IDBP-808116
FK506 binding protein 8, 38kDa
IDBP-808121
FK506 binding protein 8, 38kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:18531751-18544077
Strand Reverse strand
Band p13.11
Transcripts
ENST00000222308 ENSP00000222308
ENST00000544835 ENSP00000441267
ENST00000596558 ENSP00000472302
ENST00000594844 ENSP00000472087
ENST00000597611 ENSP00000472643
ENST00000597960 ENSP00000471700
ENST00000596015 ENSP00000475588
ENST00000599540 ENSP00000472731
ENST00000596494
ENST00000601844 ENSP00000472921
ENST00000597547 ENSP00000472043
ENST00000608443 ENSP00000476767
ENST00000606531 ENSP00000475895
ENST00000609656 ENSP00000477278
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 99 experimentally validated interaction(s) in this database.
Experimentally validated
Total 99 [view]
Protein-Protein 99 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0005528 FK506 binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0001708 cell fate specification
GO:0006457 protein folding
GO:0006915 apoptotic process
GO:0007224 smoothened signaling pathway
GO:0009953 dorsal/ventral pattern formation
GO:0010468 regulation of gene expression
GO:0016032 viral process
GO:0021904 dorsal/ventral neural tube patterning
GO:0021915 neural tube development
GO:0030510 regulation of BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0035264 multicellular organism growth
GO:0035556 intracellular signal transduction
GO:0043010 camera-type eye development
GO:0043066 negative regulation of apoptotic process
GO:0061077 chaperone-mediated protein folding
Cellular Component
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019428
View Gene Order
ENSBTAG00000016264
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
Insulin receptor signaling pathway
PID NCI
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Cross-References
SwissProt Q14318
TrEMBL A0A024R7P2 B2R8G6 J3KQ73 M0R1Q0 M0R1S6 M0R2K9 M0R2Q6 M0R304 V9GZ05
UniProt Splice Variant
Entrez Gene 23770
UniGene
RefSeq NM_012181 XM_005259841 XM_005259842 XM_005259844
HUGO HGNC:3724
OMIM 604840
CCDS CCDS32961
HPRD
IMGT
EMBL AC005387 AK222838 AK313363 AY225339 AY278607 BC009966 BX538124 BX647405 CH471106 GQ372970 L37033
GenPept AAB00102 AAC28753 AAH09966 AAO39020 AAQ84561 ACU65096 BAD96558 BAG36163 CAD98028 EAW84709 EAW84710
RNA Seq Atlas 23770

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca