InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MGST2

Summary

InnateDB Gene

IDBG-38573.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGST2

Gene Name

microsomal glutathione S-transferase 2

Synonyms

GST2; MGST-II

Species

Homo sapiens

Ensembl Gene

ENSG00000085871

Encoded Proteins

IDBP-38575

microsomal glutathione S-transferase 2

IDBP-477019

microsomal glutathione S-transferase 2

IDBP-482315

microsomal glutathione S-transferase 2

IDBP-810968

microsomal glutathione S-transferase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:139665768-139740745

Strand

Forward strand

Band

q31.1

Transcripts

ENST00000265498	ENSP00000265498
ENST00000506797	ENSP00000424278
ENST00000515137
ENST00000502587
ENST00000503816	ENSP00000423008
ENST00000515067
ENST00000616265	ENSP00000482639

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0004464	leukotriene-C4 synthase activity
GO:0004602	glutathione peroxidase activity
GO:0008047	enzyme activator activity

Biological Process

GO:0006750	glutathione biosynthetic process
GO:0006805	xenobiotic metabolic process
GO:0010243	response to organonitrogen compound
GO:0019370	leukotriene biosynthetic process
GO:0032496	response to lipopolysaccharide
GO:0043085	positive regulation of catalytic activity
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:1901687	glutathione derivative biosynthetic process

Cellular Component

GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000074604

View Gene Order

ENSBTAG00000021779

Not yet available

Pathways

NETPATH

REACTOME

REACT_6926

Glutathione conjugation pathway

REACT_228214

Aflatoxin activation and detoxification pathway

REACT_6959

Phase II conjugation pathway

REACT_111217

Metabolism pathway

REACT_13433

Biological oxidations pathway

KEGG

hsa00480

Glutathione metabolism pathway

hsa00980

Metabolism of xenobiotics by cytochrome P450 pathway

hsa00982

Drug metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.662984

RefSeq

NM_001204366 NM_001204367 NM_001204368 NM_002413

HUGO

OMIM

CCDS

CCDS3749 CCDS56339

HPRD

03436

IMGT

EMBL

GenPept

RNA Seq Atlas