Version 5.4
Homo sapiens Gene: CRLF1
Summary
InnateDB Gene IDBG-38591.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRLF1
Gene Name cytokine receptor-like factor 1
Synonyms CISS; CISS1; CLF; CLF-1; NR6; zcytor5
Species Homo sapiens
Ensembl Gene ENSG00000006016
Encoded Proteins
IDBP-245762
cytokine receptor-like factor 1
IDBP-765075
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:18572220-18607741
Strand Reverse strand
Band p13.11
Transcripts
ENST00000392386 ENSP00000376188
ENST00000596360
ENST00000597131 ENSP00000470625
ENST00000594325
ENST00000593286
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005125 cytokine activity
GO:0005127 ciliary neurotrophic factor receptor binding
GO:0005515 protein binding
GO:0019955 cytokine binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001657 ureteric bud development
GO:0008284 positive regulation of cell proliferation
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043524 negative regulation of neuron apoptotic process
GO:2000672 negative regulation of motor neuron apoptotic process
Cellular Component
GO:0005615 extracellular space
GO:0097058 CRLF-CLCF1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000007888
View Gene Order
ENSBTAG00000007741
Not yet available
Cross-References
SwissProt O75462
TrEMBL
UniProt Splice Variant
Entrez Gene 9244
UniGene Hs.114948
RefSeq NM_004750
HUGO HGNC:2364
OMIM 604237
CCDS CCDS32962
HPRD 09177
IMGT
EMBL AF059293 AF073515 AF178684 AY358291 BC044634
GenPept AAC28335 AAD39681 AAD54385 AAH44634 AAQ88658
RNA Seq Atlas 9244

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca