Version 5.4
Homo sapiens Gene: EEF1D
Summary
InnateDB Gene IDBG-38640.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EEF1D
Gene Name eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Synonyms EF-1D; EF1D; FP1047
Species Homo sapiens
Ensembl Gene ENSG00000104529
Encoded Proteins
IDBP-38646
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-240185
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-377498
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-377500
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-377501
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-585376
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-602278
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-583140
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-596927
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-590540
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-594328
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-602289
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-588080
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-588297
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-589797
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-588790
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-583574
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-591134
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-590336
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-587335
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-592825
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-600777
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-598007
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-584126
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-601695
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-600384
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-597657
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-599239
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-593384
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-590707
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-587864
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-592378
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-595543
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-597554
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-588999
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-596207
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-585867
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-586857
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-602845
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-596500
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-584108
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-587619
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-590885
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-597695
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-602192
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-600664
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-591647
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-590890
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-594270
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-813375
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:143579697-143599541
Strand Reverse strand
Band q24.3
Transcripts
ENST00000317198 ENSP00000317399
ENST00000395119 ENSP00000378551
ENST00000442189 ENSP00000391944
ENST00000423316 ENSP00000410059
ENST00000419152 ENSP00000388261
ENST00000532400 ENSP00000433784
ENST00000529576 ENSP00000435015
ENST00000530109 ENSP00000435117
ENST00000527741
ENST00000532741 ENSP00000434070
ENST00000526838 ENSP00000436507
ENST00000528610 ENSP00000431763
ENST00000533833 ENSP00000432881
ENST00000529272 ENSP00000434872
ENST00000529007 ENSP00000436045
ENST00000531621 ENSP00000432429
ENST00000524624 ENSP00000435697
ENST00000524397 ENSP00000437276
ENST00000534380 ENSP00000433611
ENST00000528382 ENSP00000436880
ENST00000534377 ENSP00000431460
ENST00000526786
ENST00000533204 ENSP00000434691
ENST00000530191 ENSP00000436542
ENST00000530616 ENSP00000431833
ENST00000531218 ENSP00000434448
ENST00000530848
ENST00000533494 ENSP00000433412
ENST00000530445 ENSP00000436933
ENST00000529516 ENSP00000431742
ENST00000534232
ENST00000533749 ENSP00000431933
ENST00000525695
ENST00000526340 ENSP00000435477
ENST00000525223 ENSP00000431613
ENST00000532543 ENSP00000434123
ENST00000531931 ENSP00000437117
ENST00000526710 ENSP00000434389
ENST00000531281 ENSP00000432221
ENST00000532596 ENSP00000432919
ENST00000524883 ENSP00000432941
ENST00000531670 ENSP00000433698
ENST00000528519 ENSP00000436251
ENST00000529832 ENSP00000437223
ENST00000530306 ENSP00000433520
ENST00000530545 ENSP00000431401
ENST00000525261 ENSP00000431285
ENST00000534804 ENSP00000433101
ENST00000524900 ENSP00000431307
ENST00000526135 ENSP00000436718
ENST00000531953 ENSP00000435719
ENST00000526133 ENSP00000435617
ENST00000534475 ENSP00000433398
ENST00000528303 ENSP00000433255
ENST00000531770
ENST00000618139 ENSP00000484536
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 84 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 84 [view]
Protein-Protein 84 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003746 translation elongation factor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008135 translation factor activity, nucleic acid binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006412 translation
GO:0006414 translational elongation
GO:0007165 signal transduction
GO:0010467 gene expression
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005853 eukaryotic translation elongation factor 1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000055762
View Gene Order
ENSBTAG00000014643
Not yet available
Pathways
NETPATH
REACTOME
REACT_1477
Eukaryotic Translation Elongation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.601547 Hs.703306 Hs.722687 Hs.732724
RefSeq NM_001130053 NM_001130055 NM_001130056 NM_001130057 NM_001195203 NM_001289950 NM_001960 NM_032378 XM_005250820 XM_005250821 XM_005250823 XM_005250824 XM_006716519 XM_006716523 XM_006716524 XM_006716525 XM_006725064 XM_006725065 XM_006725067 XM_006725070 XM_006725071 XM_006725072 XM_006725073 XM_006725075
HUGO
OMIM
CCDS CCDS47930 CCDS56559 CCDS6404 CCDS6405
HPRD 00560
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca