Version 5.4
Homo sapiens Gene: ANGPT4
Summary
InnateDB Gene IDBG-38723.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANGPT4
Gene Name angiopoietin 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101280
Encoded Proteins
IDBP-38725
angiopoietin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:869899-916317
Strand Reverse strand
Band p13
Transcripts
ENST00000381922 ENSP00000371347
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0001525 angiogenesis
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0007596 blood coagulation
GO:0010595 positive regulation of endothelial cell migration
GO:0016525 negative regulation of angiogenesis
GO:0043066 negative regulation of apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050900 leukocyte migration
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027460
View Gene Order
ENSBTAG00000021811
Not yet available
Pathways
NETPATH
REACTOME
REACT_12621
Tie2 Signaling pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9Y264
TrEMBL
UniProt Splice Variant
Entrez Gene 51378
UniGene Hs.278973
RefSeq NM_015985 XM_006723567
HUGO HGNC:487
OMIM 603705
CCDS CCDS13009
HPRD
IMGT
EMBL AF074332 AF113708 AK304756 AL050325 AL161939 BC111976 BC111978
GenPept AAD21587 AAD31728 AAI11977 AAI11979 BAG65511 CAC09933 CAI22922
RNA Seq Atlas 51378

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca