Homo sapiens Gene: SNCAIP | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-38780.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | SNCAIP | ||||||||||||||||||||||
Gene Name | synuclein, alpha interacting protein | ||||||||||||||||||||||
Synonyms | Sph1; SYPH1 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000064692 | ||||||||||||||||||||||
Encoded Proteins |
synuclein, alpha interacting protein
synuclein, alpha interacting protein
synuclein, alpha interacting protein
synuclein, alpha interacting protein
synuclein, alpha interacting protein
synuclein, alpha interacting protein
synuclein, alpha interacting protein
synuclein, alpha interacting protein
synuclein, alpha interacting protein
synuclein, alpha interacting protein
synuclein, alpha interacting protein
synuclein, alpha interacting protein
synuclein, alpha interacting protein
synuclein, alpha interacting protein
synuclein, alpha interacting protein
synuclein, alpha interacting protein
synuclein, alpha interacting protein
synuclein, alpha interacting protein
synuclein, alpha interacting protein
synuclein, alpha interacting protein
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2011] This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson\'s disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2011] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 5:122311354-122464219 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q23.2 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||
KEGG |
Parkinson's disease pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q9Y6H5 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 9627 | ||||||||||||||||||||||
UniGene | Hs.426463 Hs.740149 | ||||||||||||||||||||||
RefSeq | NM_001242935 XM_006714737 NM_005460 XM_005272138 XM_005272139 XM_006714734 XM_006714735 XM_006714736 XM_006714738 | ||||||||||||||||||||||
HUGO | HGNC:11139 | ||||||||||||||||||||||
OMIM | 603779 | ||||||||||||||||||||||
CCDS | CCDS58964 CCDS4131 | ||||||||||||||||||||||
HPRD | 04804 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB110788 AB110789 AB110790 AF076929 AF167301 AF167302 AF167303 AF167304 AF167305 AF167306 BC033743 BC040552 BC094759 CH471086 DQ227317 | ||||||||||||||||||||||
GenPept | AAD30362 AAG17478 AAH33743 AAH40552 AAH94759 ABB51162 BAD19017 BAD19018 BAD19019 EAW48889 EAW48890 | ||||||||||||||||||||||
RNA Seq Atlas | 9627 | ||||||||||||||||||||||