InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UCP1

Summary

InnateDB Gene

IDBG-38859.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UCP1

Gene Name

uncoupling protein 1 (mitochondrial, proton carrier)

Synonyms

SLC25A7; UCP

Species

Homo sapiens

Ensembl Gene

ENSG00000109424

Encoded Proteins

IDBP-38861

uncoupling protein 1 (mitochondrial, proton carrier)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:140559434-140568805

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000262999

ENSP00000262999

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017077	oxidative phosphorylation uncoupler activity

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006839	mitochondrial transport
GO:0015992	proton transport
GO:0022904	respiratory electron transport chain
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0050873	brown fat cell differentiation

Cellular Component

GO:0005739	mitochondrion
GO:0005740	mitochondrial envelope
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031710

View Gene Order

ENSBTAG00000004647

Not yet available

Pathways

NETPATH

REACTOME

REACT_6258

The fatty acid cycling model pathway

REACT_6196

The proton buffering model pathway

REACT_6305

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway

REACT_6341

Mitochondrial Uncoupling Proteins pathway

REACT_111083

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_111217

Metabolism pathway

KEGG

hsa03320

PPAR signaling pathway pathway

hsa05016

Huntington's disease pathway

INOH

PID NCI

Cross-References

SwissProt

P25874

TrEMBL

Q4KMT7

UniProt Splice Variant

Entrez Gene

7350

UniGene

Hs.249211

RefSeq

NM_021833 XM_005263206

HUGO

HGNC:12517

OMIM

113730

CCDS

CCDS3753

HPRD

IMGT

EMBL

AC108019 BC069556 BC096736 BC098168 BC098258 BC098352 U28480 X51952 X51953 X51954 X51955

GenPept

AAA85271 AAH69556 AAH96736 AAH98168 AAH98258 AAH98352 AAY41026 CAA36214

RNA Seq Atlas

7350