InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RIPK3

Summary

InnateDB Gene

IDBG-3902.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RIPK3

Gene Name

receptor-interacting serine-threonine kinase 3

Synonyms

RIP3

Species

Homo sapiens

Ensembl Gene

ENSG00000129465

Encoded Proteins

IDBP-3904

receptor-interacting serine-threonine kinase 3

IDBP-593847

receptor-interacting serine-threonine kinase 3

IDBP-601166

receptor-interacting serine-threonine kinase 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22123964

RIPK3 forms a complex with TICAM1 upon Toll-like receptors (TLR) 3 and 4 activation resulting in RIPK3-dependent but TNF-independent necrosis in macrophages. (Demonstrated in mouse)

PMID 22423968

RIPK3 interacts with ZBP1 to mediate virus-induced necrosis. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 22123964

[Mus musculus] Ripk3 forms a complex with Ticam1 upon Toll-like receptors (TLR) 3 and 4 activation resulting in Ripk3-dependent but TNF-independent necrosis in macrophages.

PMID 22423968

[Mus musculus] Ripk3 interacts with Zbp1 to mediate virus-induced necrosis.

PMID 25367573

[Mus musculus] Ripk3 has a novel function in NF-kB activation, dendritic cell biology, innate inflammatory-cytokine expression, and injury-induced tissue repair.

Entrez Gene

Summary

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:24336021-24340045

Strand

Reverse strand

Band

q12

Transcripts

ENST00000216274	ENSP00000216274
ENST00000554756	ENSP00000452328
ENST00000554569	ENSP00000451840
ENST00000557624
ENST00000557253
ENST00000554338
ENST00000557662

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004704	NF-kappaB-inducing kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0032403	protein complex binding
GO:0042802	identical protein binding

Biological Process

GO:0001914	regulation of T cell mediated cytotoxicity
GO:0002224	toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0002819	regulation of adaptive immune response
GO:0006464	cellular protein modification process
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0010922	positive regulation of phosphatase activity
GO:0032147	activation of protein kinase activity
GO:0032481	positive regulation of type I interferon production
GO:0032649	regulation of interferon-gamma production
GO:0033077	T cell differentiation in thymus
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038061	NIK/NF-kappaB signaling
GO:0043029	T cell homeostasis
GO:0045087	innate immune response (InnateDB)
GO:0046006	regulation of activated T cell proliferation
GO:0046777	protein autophosphorylation
GO:0048535	lymph node development
GO:0048536	spleen development
GO:0048538	thymus development
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051260	protein homooligomerization
GO:0051291	protein heterooligomerization
GO:0051347	positive regulation of transferase activity
GO:0051351	positive regulation of ligase activity
GO:0051353	positive regulation of oxidoreductase activity
GO:0060545	positive regulation of necroptotic process
GO:0070235	regulation of activation-induced cell death of T cells
GO:0070266	necroptotic process
GO:0090312	positive regulation of protein deacetylation
GO:0097190	apoptotic signaling pathway
GO:1990000	amyloid fibril formation
GO:2000377	regulation of reactive oxygen species metabolic process
GO:2000379	positive regulation of reactive oxygen species metabolic process
GO:2000452	regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway