InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NDC80

Summary

InnateDB Gene

IDBG-391.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDC80

Gene Name

NDC80 kinetochore complex component homolog (S. cerevisiae)

Synonyms

HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3

Species

Homo sapiens

Ensembl Gene

ENSG00000080986

Encoded Proteins

IDBP-393

NDC80 homolog, kinetochore complex component (S. cerevisiae)

IDBP-811216

NDC80 kinetochore complex component

IDBP-726821

IDBP-726819

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:2571511-2616635

Strand

Forward strand

Band

p11.32

Transcripts

ENST00000261597	ENSP00000261597
ENST00000576274	ENSP00000476919
ENST00000575515	ENSP00000461227
ENST00000574096	ENSP00000458236
ENST00000574567

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	65 [view]
Protein-Protein	61 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000132	establishment of mitotic spindle orientation
GO:0000278	mitotic cell cycle
GO:0007049	cell cycle
GO:0007051	spindle organization
GO:0007052	mitotic spindle organization
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0008608	attachment of spindle microtubules to kinetochore
GO:0016192	vesicle-mediated transport
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000942	condensed nuclear chromosome outer kinetochore
GO:0005634	nucleus
GO:0005829	cytosol
GO:0016020	membrane
GO:0031262	Ndc80 complex