Homo sapiens Gene: PPM1G
Summary
InnateDB Gene IDBG-39104.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol PPM1G
Gene Name protein phosphatase, Mg2+/Mn2+ dependent, 1G
Synonyms PP2CG; PP2CGAMMA; PPP2CG;
Species Homo sapiens
Ensembl Gene ENSG00000115241
Encoded Proteins
protein phosphatase, Mg2+/Mn2+ dependent, 1G
protein phosphatase, Mg2+/Mn2+ dependent, 1G
Protein Structure
Entrez Gene
Summary The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:27604061-27632554
Strand Reverse strand
Band p23.3
Transcripts
ENST00000344034 ENSP00000342778
ENST00000350803 ENSP00000264714
ENST00000472077
ENST00000484925
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 67 [view]
Protein-Protein 67 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0007050 cell cycle arrest
GO:0035970 peptidyl-threonine dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt O15355
TrEMBL B4DDC8 Q6IAU5 Q96IN7
UniProt Splice Variant
Entrez Gene 5496
UniGene Hs.643951
RefSeq NM_177983
HUGO 9278
OMIM 605119
CCDS CCDS1752
HPRD 09237
IMGT
EMBL AC074117 AK293141 BC000057 BC007361 BC022061 BT007454 CH471053 CR457059 Y13936
GenPept AAH00057 AAH07361 AAH22061 AAP36122 AAY14846 BAG56689 CAA74245 CAG33340 EAX00582
ImmGen PPM1G (murine)
RNA Seq Atlas 5496