Homo sapiens Gene: PPM1G

Summary
InnateDB Gene IDBG-39104.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol PPM1G
Gene Name protein phosphatase, Mg2+/Mn2+ dependent, 1G
Synonyms PP2CG; PP2CGAMMA; PPP2CG
Species Homo sapiens
Ensembl Gene ENSG00000115241
Encoded Proteins
IDBP-39106 protein phosphatase, Mg2+/Mn2+ dependent, 1G
IDBP-39108 protein phosphatase, Mg2+/Mn2+ dependent, 1G
Entrez Gene
Summary The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2: 27604061-27632554
Strand Reverse strand
Band p23.3
Transcripts
ENST00000344034  ENSP00000342778
ENST00000350803  ENSP00000264714
ENST00000472077 
ENST00000484925 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein‑Protein  23
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total 1 [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0003824 catalytic activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0007050 cell cycle arrest
GO:0035970 peptidyl-threonine dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000029147 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000019522 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O15355 
TrEMBL B4DDC8 Q6IAU5 Q96IN7
UniProt Splice Variant
Entrez Gene 5496 
UniGene Hs.643951
RefSeq NM_177983 
HUGO 9278 
OMIM 605119
CCDS CCDS1752 
HPRD 09237
IMGT
EMBL AC074117 AK293141 BC000057 BC007361 BC022061 BT007454 CH471053 CR457059 Y13936
GenPept AAH00057  AAH07361  AAH22061  AAP36122  AAY14846  BAG56689  CAA74245  CAG33340  EAX00582 
ImmGen PPM1G (murine) 
RNA Seq Atlas 5496