Version 5.4
Homo sapiens Gene: PPM1G
Summary
InnateDB Gene IDBG-39104.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPM1G
Gene Name protein phosphatase, Mg2+/Mn2+ dependent, 1G
Synonyms PP2CG; PP2CGAMMA; PPP2CG
Species Homo sapiens
Ensembl Gene ENSG00000115241
Encoded Proteins
IDBP-39106
protein phosphatase, Mg2+/Mn2+ dependent, 1G
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:27381194-27409687
Strand Reverse strand
Band p23.3
Transcripts
ENST00000344034 ENSP00000342778
ENST00000472077
ENST00000484925
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 67 [view]
Protein-Protein 67 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0007050 cell cycle arrest
GO:0035970 peptidyl-threonine dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029147
View Gene Order
ENSBTAG00000019522
Not yet available
Cross-References
SwissProt O15355
TrEMBL B4DDC8 Q6IAU5 Q96IN7
UniProt Splice Variant
Entrez Gene 5496
UniGene Hs.643951
RefSeq NM_177983
HUGO HGNC:9278
OMIM 605119
CCDS CCDS1752
HPRD
IMGT
EMBL AC074117 AK293141 BC000057 BC007361 BC022061 BT007454 CH471053 CR457059 Y13936
GenPept AAH00057 AAH07361 AAH22061 AAP36122 AAY14846 BAG56689 CAA74245 CAG33340 EAX00582
RNA Seq Atlas 5496

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca