Version 5.4
Homo sapiens Gene: GPR37
Summary
InnateDB Gene IDBG-39112.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR37
Gene Name G protein-coupled receptor 37 (endothelin receptor type B-like)
Synonyms EDNRBL; hET(B)R-LP; PAELR
Species Homo sapiens
Ensembl Gene ENSG00000170775
Encoded Proteins
IDBP-39114
G protein-coupled receptor 37 (endothelin receptor type B-like)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:124745997-124765627
Strand Reverse strand
Band q31.33
Transcripts
ENST00000303921 ENSP00000306449
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0031987 locomotion involved in locomotory behavior
GO:0042416 dopamine biosynthetic process
GO:0045964 positive regulation of dopamine metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039904
View Gene Order
ENSBTAG00000013732
Not yet available
Pathways
NETPATH
REACTOME
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa05012
Parkinson's disease pathway
INOH
PID NCI
Cross-References
SwissProt O15354
TrEMBL
UniProt Splice Variant
Entrez Gene 2861
UniGene
RefSeq NM_005302
HUGO HGNC:4494
OMIM 602583
CCDS CCDS5792
HPRD
IMGT
EMBL AC004925 AF017262 AF502281 BC040007 CH236947 CH471070 U87460 Y12476 Y12477
GenPept AAB70008 AAC51281 AAD08853 AAH40007 AAM18625 CAA73080 EAL24325 EAW83613
RNA Seq Atlas 2861

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca