Version 5.4
Homo sapiens Gene: CRLF3
Summary
InnateDB Gene IDBG-39171.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRLF3
Gene Name cytokine receptor-like factor 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000176390
Encoded Proteins
IDBP-39173
cytokine receptor-like factor 3
IDBP-762143
IDBP-764754
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:30769388-30824776
Strand Reverse strand
Band q11.2
Transcripts
ENST00000324238 ENSP00000318804
ENST00000578692 ENSP00000462643
ENST00000577725
ENST00000583805
ENST00000583527 ENSP00000463689
ENST00000585268
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0030308 negative regulation of cell growth
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046427 positive regulation of JAK-STAT cascade
GO:0071158 positive regulation of cell cycle arrest
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017561
View Gene Order
ENSBTAG00000018381
Not yet available
Cross-References
SwissProt Q8IUI8
TrEMBL B4DJU5 J3KST8 L8E8Q9
UniProt Splice Variant
Entrez Gene 51379
UniGene Hs.370168 Hs.649372
RefSeq NM_015986 XM_006721941
HUGO HGNC:17177
OMIM 614853
CCDS CCDS32607
HPRD
IMGT
EMBL AC127024 AF046059 AF120151 AK296238 AK313315 BC023567 DQ298450 HF584032
GenPept AAD02422 AAD31758 AAH23567 ABC55264 BAG36120 BAG58957 CCQ43529
RNA Seq Atlas 51379

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca