Version 5.4
Homo sapiens Gene: GAB1
Summary
InnateDB Gene IDBG-39257.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAB1
Gene Name GRB2-associated binding protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000109458
Encoded Proteins
IDBP-39259
GRB2-associated binding protein 1
IDBP-39261
GRB2-associated binding protein 1
IDBP-481808
GRB2-associated binding protein 1
IDBP-480986
GRB2-associated binding protein 1
IDBP-481861
GRB2-associated binding protein 1
IDBP-484441
GRB2-associated binding protein 1
IDBP-478951
GRB2-associated binding protein 1
IDBP-480067
GRB2-associated binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20435932
GAB1 inhibits vesicular stomatitis virus (VSV) replication and VSV infection-induced cell damage by inducing type I IFNs and IFN-inducible gene expression via the PI3K/Akt pathway. It is needed for full activation of TLR3/4- and RIG-I-triggered innate responses by promoting activation of PI3K/Akt, MAPKs, and NF-kappaB pathways.
Entrez Gene
Summary The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:143336762-143474568
Strand Forward strand
Band q31.21
Transcripts
ENST00000262995 ENSP00000262995
ENST00000262994 ENSP00000262994
ENST00000514639 ENSP00000427435
ENST00000515366 ENSP00000426668
ENST00000505913 ENSP00000424554
ENST00000515388
ENST00000509992 ENSP00000425921
ENST00000511836 ENSP00000420867
ENST00000512843 ENSP00000426297
ENST00000507334
ENST00000507070
ENST00000510615
ENST00000508833
ENST00000511109
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 92 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 92 [view]
Protein-Protein 91 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0006979 response to oxidative stress
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007257 activation of JUN kinase activity
GO:0007507 heart development
GO:0008283 cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008544 epidermis development
GO:0030334 regulation of cell migration
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043410 positive regulation of MAPK cascade
GO:0045087 innate immune response (InnateDB)
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0060711 labyrinthine layer development
GO:0070102 interleukin-6-mediated signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031714
View Gene Order
ENSBTAG00000002813
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_9
TNFalpha pathway
NetPath_12
BCR pathway
NetPath_15
IL3 pathway
NetPath_18
IL6 pathway
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_115852
Signaling by constitutively active EGFR pathway
REACT_121398
Signaling by FGFR mutants pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
KEGG
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa05100
Bacterial invasion of epithelial cells pathway
INOH
INOH website
FGF signaling pathway pathway
INOH website
HGF signaling pathway pathway
PID NCI
pi3kplctrkpathway
Trk receptor signaling mediated by PI3K and PLC-gamma
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
lysophospholipid_pathway
LPA receptor mediated events
erbb1_downstream_pathway
ErbB1 downstream signaling
epopathway
EPO signaling pathway
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
fgf_pathway
FGF signaling pathway
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
tcptp_pathway
Signaling events mediated by TCPTP
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
ret_pathway
Signaling events regulated by Ret tyrosine kinase
shp2_pathway
SHP2 signaling
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.597973 Hs.80720
RefSeq NM_002039 NM_207123 XM_006714167 XM_006714168
HUGO
OMIM
CCDS CCDS3759 CCDS3760
HPRD 05116
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca