InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CAT

Summary

InnateDB Gene

IDBG-39262.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAT

Gene Name

catalase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000121691

Encoded Proteins

IDBP-39264

catalase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer\'s disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:34438925-34472062

Strand

Forward strand

Band

p13

Transcripts

ENST00000241052	ENSP00000241052
ENST00000528104
ENST00000530343
ENST00000525707
ENST00000534710

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004046	aminoacylase activity
GO:0004096	catalase activity
GO:0005102	receptor binding
GO:0016209	antioxidant activity
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0050661	NADP binding

Biological Process

GO:0000302	response to reactive oxygen species
GO:0001649	osteoblast differentiation
GO:0001657	ureteric bud development
GO:0001666	response to hypoxia
GO:0001822	kidney development
GO:0006144	purine nucleobase metabolic process
GO:0006195	purine nucleotide catabolic process
GO:0006641	triglyceride metabolic process
GO:0006979	response to oxidative stress
GO:0007568	aging
GO:0008203	cholesterol metabolic process
GO:0009060	aerobic respiration
GO:0009650	UV protection
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0020027	hemoglobin metabolic process
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0033197	response to vitamin E
GO:0042744	hydrogen peroxide catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051262	protein tetramerization
GO:0051289	protein homotetramerization
GO:0051781	positive regulation of cell division
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055093	response to hyperoxia
GO:0055114	oxidation-reduction process
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0005764	lysosome
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005782	peroxisomal matrix
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027187

View Gene Order

ENSBTAG00000020980

Not yet available

Pathways

NETPATH

REACTOME

REACT_2086

Purine catabolism pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_120956

Cellular responses to stress pathway

REACT_522

Purine metabolism pathway

REACT_172715

Detoxification of Reactive Oxygen Species pathway

REACT_111217

Metabolism pathway

KEGG

hsa00630

Glyoxylate and dicarboxylate metabolism pathway

hsa00380

Tryptophan metabolism pathway

hsa05014

Amyotrophic lateral sclerosis (ALS) pathway

hsa04146

Peroxisome pathway

INOH

INOH website

Tryptophan degradation pathway

PID NCI

foxopathway

FoxO family signaling

Cross-References

SwissProt

P04040

TrEMBL

Q8TAK2

UniProt Splice Variant

Entrez Gene

847

UniGene

Hs.502302

RefSeq

NM_001752

HUGO

HGNC:1516

OMIM

115500

CCDS

CCDS7891

HPRD

00282

IMGT

EMBL

AK291585 AK315350 AL035079 AY028632 AY545477 BC027300 BC110398 BC112217 BC112219 CH471064 K02400 L13609 X04076 X04085 X04086 X04087 X04088 X04089 X04090 X04091 X04092 X04093 X04094 X04095 X04096

GenPept

AAA16651 AAB59522 AAH27300 AAI10399 AAI12218 AAI12220 AAK29181 AAS37679 BAF84274 BAG37746 CAA27717 CAA27721 CAB45236 EAW68170 EAW68171

RNA Seq Atlas

847