Homo sapiens Gene: PUF60 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-39284.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | PUF60 | ||||||||||||||||||
Gene Name | poly-U binding splicing factor 60KDa | ||||||||||||||||||
Synonyms | FIR; RoBPI; SIAHBP1; VRJS | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000179950 | ||||||||||||||||||
Encoded Proteins |
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 8:143816344-143829859 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q24.3 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 113 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH |
TSLP pathway
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REACTOME | |||||||||||||||||||
KEGG |
Spliceosome pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9UHX1 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 22827 | ||||||||||||||||||
UniGene | Hs.521924 | ||||||||||||||||||
RefSeq | NM_001271097 NM_001136033 NM_001271096 NM_001271098 NM_001271099 NM_001271100 NM_014281 NM_078480 | ||||||||||||||||||
HUGO | HGNC:17042 | ||||||||||||||||||
OMIM | 604819 | ||||||||||||||||||
CCDS | CCDS59515 CCDS47933 CCDS47934 CCDS47935 CCDS59514 CCDS59516 | ||||||||||||||||||
HPRD | 18051 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AF114818 AF190744 AF217197 AK292373 BC008875 BC009734 BC011265 BC011979 CH471162 CR457143 U51586 | ||||||||||||||||||
GenPept | AAB41656 AAF05605 AAF23589 AAF27522 AAH08875 AAH09734 AAH11265 AAH11979 BAF85062 CAG33424 EAW82187 EAW82189 | ||||||||||||||||||
RNA Seq Atlas | 22827 | ||||||||||||||||||