Version 5.4
Homo sapiens Gene: PBRM1
Summary
InnateDB Gene IDBG-39289.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PBRM1
Gene Name polybromo 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163939
Encoded Proteins
IDBP-39293
polybromo 1
IDBP-39295
polybromo 1
IDBP-39297
polybromo 1
IDBP-240729
polybromo 1
IDBP-295699
polybromo 1
IDBP-295702
polybromo 1
IDBP-295697
polybromo 1
IDBP-295695
polybromo 1
IDBP-379531
polybromo 1
IDBP-379543
polybromo 1
IDBP-379544
polybromo 1
IDBP-379545
polybromo 1
IDBP-379546
polybromo 1
IDBP-379547
polybromo 1
IDBP-379549
polybromo 1
IDBP-379552
polybromo 1
IDBP-379554
polybromo 1
IDBP-379555
polybromo 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:52545352-52685917
Strand Reverse strand
Band p21.1
Transcripts
ENST00000356770 ENSP00000349213
ENST00000337303 ENSP00000338302
ENST00000296302 ENSP00000296302
ENST00000394830 ENSP00000378307
ENST00000409057 ENSP00000386593
ENST00000410007 ENSP00000386529
ENST00000409114 ENSP00000386643
ENST00000409767 ENSP00000386601
ENST00000412587 ENSP00000404579
ENST00000423351 ENSP00000387775
ENST00000446103 ENSP00000397662
ENST00000431678 ENSP00000409939
ENST00000420148 ENSP00000389390
ENST00000449505 ENSP00000412401
ENST00000450271 ENSP00000416851
ENST00000439181 ENSP00000404635
ENST00000458294 ENSP00000411895
ENST00000424867 ENSP00000397399
ENST00000462207
ENST00000480064
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0001890 placenta development
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007067 mitotic nuclear division
GO:0007507 heart development
GO:0008285 negative regulation of cell proliferation
Cellular Component
GO:0000228 nuclear chromosome
GO:0000776 kinetochore
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042323
View Gene Order
ENSBTAG00000014786
Not yet available
Pathways
NETPATH
REACTOME
REACT_172623
Chromatin organization pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.189920 Hs.734413
RefSeq NM_018313 XM_005265288 XM_006713223 XM_006713229 XM_006713232 XM_006713233 XM_006713234
HUGO
OMIM
CCDS CCDS43099
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca