Version 5.4
Homo sapiens Gene: CRLF2
Summary
InnateDB Gene IDBG-39359.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRLF2
Gene Name cytokine receptor-like factor 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000205755
Encoded Proteins
IDBP-39361
cytokine receptor-like factor 2
IDBP-39363
cytokine receptor-like factor 2
IDBP-227281
cytokine receptor-like factor 2
IDBP-810696
cytokine receptor-like factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome X:1187549-1212750
Strand Reverse strand
Band p22.33
Transcripts
ENST00000381567 ENSP00000370979
ENST00000381566 ENSP00000370978
ENST00000400841 ENSP00000383641
ENST00000467626 ENSP00000485269
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002380 immunoglobulin secretion involved in immune response
GO:0006954 inflammatory response
GO:0035745 T-helper 2 cell cytokine production
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.287729
RefSeq NM_001012288 NM_022148
HUGO
OMIM
CCDS CCDS75944 CCDS75945
HPRD 02288
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca