Version 5.4
Homo sapiens Gene: NQO1
Summary
InnateDB Gene IDBG-39427.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NQO1
Gene Name NAD(P)H dehydrogenase, quinone 1
Synonyms DHQU; DIA4; DTD; NMOR1; NMORI; QR1
Species Homo sapiens
Ensembl Gene ENSG00000181019
Encoded Proteins
IDBP-39429
NAD(P)H dehydrogenase, quinone 1
IDBP-39431
NAD(P)H dehydrogenase, quinone 1
IDBP-39433
NAD(P)H dehydrogenase, quinone 1
IDBP-379811
NAD(P)H dehydrogenase, quinone 1
IDBP-746167
IDBP-746115
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein\'s enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer\'s disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:69706996-69726951
Strand Reverse strand
Band q22.1
Transcripts
ENST00000320623 ENSP00000319788
ENST00000379047 ENSP00000368335
ENST00000379046 ENSP00000368334
ENST00000439109 ENSP00000398330
ENST00000564043 ENSP00000455020
ENST00000561500 ENSP00000456282
ENST00000569118
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 20 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003955 NAD(P)H dehydrogenase (quinone) activity
GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0004784 superoxide dismutase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006521 regulation of cellular amino acid metabolic process
GO:0006801 superoxide metabolic process
GO:0006805 xenobiotic metabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0006979 response to oxidative stress
GO:0007271 synaptic transmission, cholinergic
GO:0007568 aging
GO:0007584 response to nutrient
GO:0009636 response to toxic substance
GO:0014070 response to organic cyclic compound
GO:0019430 removal of superoxide radicals
GO:0032355 response to estradiol
GO:0034641 cellular nitrogen compound metabolic process
GO:0043086 negative regulation of catalytic activity
GO:0043525 positive regulation of neuron apoptotic process
GO:0044281 small molecule metabolic process
GO:0045471 response to ethanol
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043025 neuronal cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003849
View Gene Order
ENSBTAG00000020632
Not yet available
Pathways
NETPATH
REACTOME
REACT_13565
Regulation of ornithine decarboxylase (ODC) pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00130
Ubiquinone and other terpenoid-quinone biosynthesis pathway
INOH
PID NCI
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt P15559
TrEMBL B4DLR8 B4DQP5 H3BNV2 H3BRK3
UniProt Splice Variant
Entrez Gene 1728
UniGene Hs.406515
RefSeq NM_000903 NM_001025433 NM_001025434 NM_001286137
HUGO HGNC:2874
OMIM 125860
CCDS CCDS10883 CCDS32471 CCDS32472 CCDS67067
HPRD
IMGT
EMBL AC092115 AK297125 AK297979 AK298896 AK312368 AK316246 AY281093 BC007659 CH471092 J03934 M81596 M81597 M81598 M81599 M81600
GenPept AAA59940 AAB60701 AAH07659 AAP20940 BAG35286 BAG59630 BAG60289 BAG61007 BAH14617 EAW83282 EAW83283 EAW83284
RNA Seq Atlas 1728

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca