Version 5.4
Homo sapiens Gene: GYPA
Summary
InnateDB Gene IDBG-39590.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GYPA
Gene Name glycophorin A (MNS blood group)
Synonyms CD235a; GPA; GPErik; GPSAT; HGpMiV; HGpMiXI; HGpSta(C); MN; MNS; PAS-2
Species Homo sapiens
Ensembl Gene ENSG00000170180
Encoded Proteins
IDBP-39592
glycophorin A (MNS blood group)
IDBP-39594
glycophorin A (MNS blood group)
IDBP-477544
glycophorin A (MNS blood group)
IDBP-481718
glycophorin A (MNS blood group)
IDBP-478575
glycophorin A (MNS blood group)
IDBP-483526
glycophorin A (MNS blood group)
IDBP-477700
glycophorin A (MNS blood group)
IDBP-590233
glycophorin A (MNS blood group)
IDBP-812598
glycophorin A (MNS blood group)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:144109303-144140751
Strand Reverse strand
Band q31.21
Transcripts
ENST00000360771 ENSP00000354003
ENST00000324022 ENSP00000324483
ENST00000510771
ENST00000508337 ENSP00000425719
ENST00000512064 ENSP00000426130
ENST00000512789 ENSP00000425193
ENST00000504786 ENSP00000425549
ENST00000503627 ENSP00000421243
ENST00000509346
ENST00000514603
ENST00000535709 ENSP00000445398
ENST00000616983 ENSP00000478329
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0003674 molecular_function
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0007016 cytoskeletal anchoring at plasma membrane
GO:0008150 biological_process
GO:0009615 response to virus
GO:0016032 viral process
GO:0047484 regulation of response to osmotic stress
Cellular Component
GO:0005575 cellular_component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa05144
Malaria pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.434973
RefSeq NM_002099
HUGO
OMIM
CCDS CCDS34069
HPRD 07508
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca