Version 5.4
Homo sapiens Gene: TMPRSS2
Summary
InnateDB Gene IDBG-3965.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMPRSS2
Gene Name transmembrane protease, serine 2
Synonyms PP9284; PRSS10
Species Homo sapiens
Ensembl Gene ENSG00000184012
Encoded Proteins
IDBP-3967
transmembrane protease, serine 2
IDBP-232716
transmembrane protease, serine 2
IDBP-367208
transmembrane protease, serine 2
IDBP-367210
transmembrane protease, serine 2
IDBP-367211
transmembrane protease, serine 2
IDBP-367213
transmembrane protease, serine 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:41464551-41531116
Strand Reverse strand
Band q22.3
Transcripts
ENST00000332149 ENSP00000330330
ENST00000398585 ENSP00000381588
ENST00000458356 ENSP00000391216
ENST00000454499 ENSP00000389006
ENST00000424093 ENSP00000397846
ENST00000455813 ENSP00000391784
ENST00000488556
ENST00000469395
ENST00000497881
ENST00000463138
ENST00000489201
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006898 receptor-mediated endocytosis
GO:0016540 protein autoprocessing
GO:0046598 positive regulation of viral entry into host cell
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000385
View Gene Order
ENSBTAG00000009132
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
ar_pathway
Coregulation of Androgen receptor activity
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.439309 Hs.733848
RefSeq NM_001135099 NM_005656
HUGO
OMIM
CCDS CCDS33564 CCDS54486
HPRD 03637
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca