Version 5.4
Homo sapiens Gene: IMPDH1
Summary
InnateDB Gene IDBG-39659.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IMPDH1
Gene Name IMP (inosine 5'-monophosphate) dehydrogenase 1
Synonyms IMPD; IMPD1; LCA11; RP10; sWSS2608
Species Homo sapiens
Ensembl Gene ENSG00000106348
Encoded Proteins
IDBP-39661
IMP (inosine 5'-monophosphate) dehydrogenase 1
IDBP-39665
IMP (inosine 5'-monophosphate) dehydrogenase 1
IDBP-39669
IMP (inosine 5'-monophosphate) dehydrogenase 1
IDBP-386099
IMP (inosine 5'-monophosphate) dehydrogenase 1
IDBP-480789
IMP (inosine 5'-monophosphate) dehydrogenase 1
IDBP-474369
IMP (inosine 5'-monophosphate) dehydrogenase 1
IDBP-476869
IMP (inosine 5'-monophosphate) dehydrogenase 1
IDBP-482374
IMP (inosine 5'-monophosphate) dehydrogenase 1
IDBP-473619
IMP (inosine 5'-monophosphate) dehydrogenase 1
IDBP-477314
IMP (inosine 5'-monophosphate) dehydrogenase 1
IDBP-481128
IMP (inosine 5'-monophosphate) dehydrogenase 1
IDBP-483216
IMP (inosine 5'-monophosphate) dehydrogenase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5\'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:128392277-128410252
Strand Reverse strand
Band q32.1
Transcripts
ENST00000338791 ENSP00000345096
ENST00000348127 ENSP00000265385
ENST00000354269 ENSP00000346219
ENST00000419067 ENSP00000399400
ENST00000469328 ENSP00000420756
ENST00000484496 ENSP00000418742
ENST00000496200 ENSP00000420803
ENST00000470772 ENSP00000417296
ENST00000480861 ENSP00000420185
ENST00000460045
ENST00000497868 ENSP00000419609
ENST00000468842
ENST00000489263 ENSP00000418592
ENST00000496487
ENST00000491376
ENST00000473463 ENSP00000420469
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0018580 nitronate monooxygenase activity
GO:0030554 adenyl nucleotide binding
GO:0046872 metal ion binding
Biological Process
GO:0006144 purine nucleobase metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046651 lymphocyte proliferation
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003500
View Gene Order
ENSBTAG00000000296
Not yet available
Pathways
NETPATH
REACTOME
REACT_1776
Purine ribonucleoside monophosphate biosynthesis pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_522
Purine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00230
Purine metabolism pathway
hsa00983
Drug metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL A0A024R725 C9J381
UniProt Splice Variant
Entrez Gene 3614
UniGene Hs.654401
RefSeq NM_001142573 NM_000883 NM_001102605 NM_001142574 NM_001142575 NM_001142576 NM_183243 XM_005250313 XM_005250314 XM_006715967 XM_006715968 XM_006715969 XM_006715970 XM_006715971 XM_006715972 XM_006715973
HUGO HGNC:6052
OMIM 146690
CCDS CCDS34748 CCDS34749 CCDS43643 CCDS47699 CCDS47700 CCDS55161
HPRD 08853
IMGT
EMBL AC010655 CH471070
GenPept EAW83651 EAW83653
RNA Seq Atlas 3614

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca