Version 5.4
Homo sapiens Gene: ITIH1
Summary
InnateDB Gene IDBG-39685.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITIH1
Gene Name inter-alpha-trypsin inhibitor heavy chain 1
Synonyms H1P; IATIH; IGHEP1; ITI-HC1; ITIH; SHAP
Species Homo sapiens
Ensembl Gene ENSG00000055957
Encoded Proteins
IDBP-39687
inter-alpha (globulin) inhibitor H1
IDBP-295671
inter-alpha (globulin) inhibitor H1
IDBP-379681
inter-alpha (globulin) inhibitor H1
IDBP-481855
inter-alpha (globulin) inhibitor H1
IDBP-480626
inter-alpha (globulin) inhibitor H1
IDBP-597303
inter-alpha (globulin) inhibitor H1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the heavy chain of a serine protease inhibitor that may serve to carry hyaluronan in plasma. This gene is part of a cluster of similar genes on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:52777592-52792068
Strand Forward strand
Band p21.1
Transcripts
ENST00000273283 ENSP00000273283
ENST00000405128 ENSP00000384589
ENST00000428133 ENSP00000395836
ENST00000480409 ENSP00000417340
ENST00000487686
ENST00000478667
ENST00000494603
ENST00000484844 ENSP00000419957
ENST00000482836
ENST00000494705
ENST00000537050 ENSP00000443847
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005509 calcium ion binding
GO:0009982 pseudouridine synthase activity
Biological Process
GO:0001522 pseudouridine synthesis
GO:0009451 RNA modification
GO:0010951 negative regulation of endopeptidase activity
GO:0030212 hyaluronan metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006529
View Gene Order
ENSBTAG00000007843
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.420257
RefSeq NM_001166434 NM_001166435 NM_001166436 NM_002215
HUGO
OMIM
CCDS CCDS2864 CCDS54595
HPRD 00927
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca