Version 5.4
Homo sapiens Gene: SUOX
Summary
InnateDB Gene IDBG-39701.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SUOX
Gene Name sulfite oxidase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139531
Encoded Proteins
IDBP-39703
sulfite oxidase
IDBP-39705
sulfite oxidase
IDBP-242264
sulfite oxidase
IDBP-242266
sulfite oxidase
IDBP-586176
sulfite oxidase
IDBP-595785
sulfite oxidase
IDBP-601198
sulfite oxidase
IDBP-602883
sulfite oxidase
IDBP-584192
sulfite oxidase
IDBP-593916
sulfite oxidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:55997180-56006641
Strand Forward strand
Band q13.2
Transcripts
ENST00000266971 ENSP00000266971
ENST00000356124 ENSP00000348440
ENST00000394115 ENSP00000377674
ENST00000394109 ENSP00000377668
ENST00000550121
ENST00000552363
ENST00000551698
ENST00000550340
ENST00000547586 ENSP00000448637
ENST00000552258 ENSP00000450049
ENST00000548274 ENSP00000450245
ENST00000552813
ENST00000550478
ENST00000546833 ENSP00000449872
ENST00000551841 ENSP00000449443
ENST00000546712
ENST00000550065 ENSP00000450264
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008482 sulfite oxidase activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0030151 molybdenum ion binding
GO:0043546 molybdopterin cofactor binding
GO:0046872 metal ion binding
Biological Process
GO:0000096 sulfur amino acid metabolic process
GO:0000098 sulfur amino acid catabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0070221 sulfide oxidation, using sulfide:quinone oxidoreductase
Cellular Component
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049858
View Gene Order
ENSBTAG00000006160
Not yet available
Pathways
NETPATH
REACTOME
REACT_116010
Sulfide oxidation to sulfate pathway
REACT_115654
Degradation of cysteine and homocysteine pathway
REACT_115639
Sulfur amino acid metabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00920
Sulfur metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F8VPA2 F8VRK9
UniProt Splice Variant
Entrez Gene 6821
UniGene
RefSeq NM_000456 NM_001032386 NM_001032387 XM_005269112
HUGO HGNC:11460
OMIM 606887
CCDS CCDS8901
HPRD 06055
IMGT
EMBL AC034102
GenPept
RNA Seq Atlas 6821

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca