Version 5.4
Homo sapiens Gene: ERBB3
Summary
InnateDB Gene IDBG-39824.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERBB3
Gene Name v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Synonyms c-erbB-3; c-erbB3; ErbB-3; erbB3-S; HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3
Species Homo sapiens
Ensembl Gene ENSG00000065361
Encoded Proteins
IDBP-39826
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
IDBP-377494
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
IDBP-377495
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
IDBP-600090
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
IDBP-592792
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
IDBP-586723
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
IDBP-588172
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
IDBP-595143
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
IDBP-585349
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
IDBP-813510
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
IDBP-596547
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
IDBP-590621
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
IDBP-588204
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56079857-56103505
Strand Forward strand
Band q13.2
Transcripts
ENST00000267101 ENSP00000267101
ENST00000411731 ENSP00000415753
ENST00000415288 ENSP00000408340
ENST00000549282 ENSP00000448636
ENST00000549061 ENSP00000449138
ENST00000550869 ENSP00000448671
ENST00000551085 ENSP00000448483
ENST00000546884
ENST00000551242 ENSP00000447510
ENST00000549672 ENSP00000449713
ENST00000549472
ENST00000546748
ENST00000551176
ENST00000549205
ENST00000550828 ENSP00000482073
ENST00000550070 ENSP00000448946
ENST00000549644
ENST00000553131 ENSP00000449129
ENST00000548709
ENST00000549832 ENSP00000448729
ENST00000552691
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 82 [view]
Protein-Protein 81 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 receptor signaling protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019838 growth factor binding
GO:0030296 protein tyrosine kinase activator activity
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0003197 endocardial cushion development
GO:0006468 protein phosphorylation
GO:0007162 negative regulation of cell adhesion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007422 peripheral nervous system development
GO:0007507 heart development
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009968 negative regulation of signal transduction
GO:0014037 Schwann cell differentiation
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021545 cranial nerve development
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042060 wound healing
GO:0042127 regulation of cell proliferation
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051048 negative regulation of secretion
GO:0051402 neuron apoptotic process
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018166
View Gene Order
ENSBTAG00000010444
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_9
TNFalpha pathway
NetPath_18
IL6 pathway
NetPath_114
Oncostatin_M pathway
REACTOME
KEGG
hsa04012
ErbB signaling pathway pathway
hsa04020
Calcium signaling pathway pathway
hsa04144
Endocytosis pathway
INOH
PID NCI
a6b1_a6b4_integrin_pathway
a6b1 and a6b4 Integrin signaling
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
erbb_network_pathway
ErbB receptor signaling network
Cross-References
SwissProt
TrEMBL B4DGQ7 F8VRL0 F8VW48 F8VX90 Q9NNX2
UniProt Splice Variant
Entrez Gene 2065
UniGene Hs.118681 Hs.622058
RefSeq NM_001005915 NM_001982
HUGO HGNC:3431
OMIM 190151
CCDS CCDS31833 CCDS44918
HPRD 01820
IMGT
EMBL AC034102 AK294719 U88356
GenPept AAF86628 BAG57868
RNA Seq Atlas 2065

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca