Version 5.4
Homo sapiens Gene: PA2G4
Summary
InnateDB Gene IDBG-39891.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PA2G4
Gene Name proliferation-associated 2G4, 38kDa
Synonyms EBP1; HG4-1; p38-2G4
Species Homo sapiens
Ensembl Gene ENSG00000170515
Encoded Proteins
IDBP-39893
proliferation-associated 2G4, 38kDa
IDBP-594673
proliferation-associated 2G4, 38kDa
IDBP-599911
proliferation-associated 2G4, 38kDa
IDBP-596067
proliferation-associated 2G4, 38kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56104319-56113907
Strand Forward strand
Band q13.2
Transcripts
ENST00000303305 ENSP00000302886
ENST00000552766 ENSP00000448557
ENST00000553057 ENSP00000447615
ENST00000551061 ENSP00000447389
ENST00000550166
ENST00000552528
ENST00000552266
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 98 experimentally validated interaction(s) in this database.
Experimentally validated
Total 98 [view]
Protein-Protein 88 [view]
Protein-DNA 10 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0031625 ubiquitin protein ligase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006364 rRNA processing
GO:0006417 regulation of translation
GO:0007050 cell cycle arrest
GO:0008152 metabolic process
GO:0008283 cell proliferation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025364
View Gene Order
ENSBTAG00000010451
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
ar_pathway
Coregulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.524498
RefSeq NM_006191
HUGO
OMIM
CCDS CCDS8902
HPRD 03685
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca