InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SMAD1

Summary

InnateDB Gene

IDBG-39936.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMAD1

Gene Name

SMAD family member 1

Synonyms

BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1

Species

Homo sapiens

Ensembl Gene

ENSG00000170365

Encoded Proteins

IDBP-39938

SMAD family member 1

IDBP-242303

SMAD family member 1

IDBP-478868

SMAD family member 1

IDBP-482704

SMAD family member 1

IDBP-479175

SMAD family member 1

IDBP-476954

SMAD family member 1

IDBP-478104

SMAD family member 1

IDBP-474347

SMAD family member 1

IDBP-473515

SMAD family member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene \'mothers against decapentaplegic\' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:145481194-145558079

Strand

Forward strand

Band

q31.21

Transcripts

ENST00000302085	ENSP00000305769
ENST00000394092	ENSP00000377652
ENST00000514778	ENSP00000424959
ENST00000507594	ENSP00000424649
ENST00000514831	ENSP00000425270
ENST00000512019	ENSP00000427002
ENST00000503324	ENSP00000422706
ENST00000515527
ENST00000507367	ENSP00000421601
ENST00000515385	ENSP00000426568
ENST00000514168
ENST00000506626
ENST00000502342
ENST00000511125
ENST00000510948
ENST00000511255

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 268 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	268 [view]
Protein-Protein	259 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	5 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0070410	co-SMAD binding
GO:0070411	I-SMAD binding

Biological Process

GO:0000165	MAPK cascade
GO:0001657	ureteric bud development
GO:0001710	mesodermal cell fate commitment
GO:0001822	kidney development
GO:0002051	osteoblast fate commitment
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007183	SMAD protein complex assembly
GO:0007276	gamete generation
GO:0008285	negative regulation of cell proliferation
GO:0009880	embryonic pattern specification
GO:0010243	response to organonitrogen compound
GO:0010628	positive regulation of gene expression
GO:0010656	negative regulation of muscle cell apoptotic process
GO:0030509	BMP signaling pathway
GO:0030901	midbrain development
GO:0030902	hindbrain development
GO:0031053	primary miRNA processing
GO:0042060	wound healing
GO:0042493	response to drug
GO:0042592	homeostatic process
GO:0045597	positive regulation of cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050775	positive regulation of dendrite morphogenesis
GO:0051216	cartilage development
GO:0060038	cardiac muscle cell proliferation
GO:0060348	bone development
GO:0061036	positive regulation of cartilage development
GO:0071407	cellular response to organic cyclic compound
GO:0071773	cellular response to BMP stimulus
GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005637	nuclear inner membrane
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0016021	integral component of membrane
GO:0043234	protein complex